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P2RX7 — TNF

Text-mined interactions from Literome

Zhang et al., Sheng Li Xue Bao 2005 : P2X7 receptor expression in PBMC was up-regulated by interleukin-2, -4, -6 ( IL-2, IL-4, IL-6 ) tumour necrosis factor-alpha (TNF-alpha) , lipopolysaccharide (LPS) and heat inactivated Staphylococcus aureus Cowan strain I ( SAC ) ... Furthermore, LPS and M-CSF could up-regulate P2X7 receptor expression in monocytes, while IFN-gamma, TNF-alpha and GM-CSF had weak effects, but pretreatment with these inducers could not further enhance LPS stimulated P2X7 receptor expression in monocytes
Suzuki et al., J Neurosci Res 2006 (Calcium Signaling...) : Here we report that, in rat primary cultured microglia, nicotine enhances P2X(7) receptor mediated TNF release, whilst suppressing LPS induced TNF release but without affecting TNF mRNA expression via activation of alpha7 nicotinic acetylcholine receptors ( alpha7 nAChRs )
Zhang et al., Proc Natl Acad Sci U S A 2007 : We further show that activation of P2X7 receptors can lead to the release of tumor necrosis factor-alpha (TNFalpha) from satellite cells
Friedle et al., Glia 2011 (Inflammation) : Moreover, using RNAi, we demonstrate that Egr factors and P2X7 receptors are necessary for BzATP mediated attenuation of iNOS, and stimulation of TNF-a and IL-6 gene expression