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PI3 — TNFSF10
Text-mined interactions from Literome
Musgrave et al., Exp Cell Res 1999
:
The PKC inhibitors staurosporine and calphostin C, and the
phosphatidylinositol 3-kinase (PI3-K) inhibitors wortmannin and LY294002, also
prevented TRAIL mRNA transcription by activated T cells, indicating a role for PKC and PI3-K
Beresford et al., J Interferon Cytokine Res 2001
(Prostatic Neoplasms) :
Suppression of
PI3'-kinase/Akt signaling markedly
enhanced the apoptotic activity of both TNF and
TRAIL in LNCaP cells but not in PC-3 cells
Wang et al., J Biol Chem 2002
:
Activation of
PI 3-kinase by pretreatment with IGF-1, a gut trophic factor, markedly
attenuated the induction of
TRAIL by wortmannin ... Taken together, our findings demonstrate
induction of the
TRAIL by inhibition of
PI 3-kinase in colon cancer cell lines
Milani et al., J Neurochem 2003
(Neuroblastoma) :
Moreover,
TRAIL increased CREB phosphorylation and phospho-CREB DNA binding activity in a
phosphatidylinositol 3-kinase (PI 3K)/Akt dependent manner
Balzarolo et al., Eur J Immunol 2012
:
Furthermore,
PI3K signaling is
required for NAB2 mediated
TRAIL expression