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ANGPT1 — IL1B

Text-mined interactions from Literome

Fan et al., Cancer Res 2004 : Interleukin-1beta regulates angiopoietin-1 expression in human endothelial cells ... Both IL-1beta and tumor necrosis factor-alpha caused marked down-regulation of Ang-1 mRNA levels at 4 h with a further decrease observed at 24 h. Using signaling inhibitors, we identified the P38 pathway as the pathway that mediates IL-1beta down-regulation of Ang-1 ... These results suggest that IL-1beta indirectly regulates angiogenesis by modulating the expression of Ang-1
Kalinski et al., Cancer 2006 (Chondroma...) : As interleukin (IL)-1beta has been found to be an indispensable factor in angiogenic signaling, we further analyzed the effect of IL-1beta on the expression of VEGF-A, Ang-1 , and Ang-2 using a previously established cell culture model ... IL-1beta regulated VEGF-A and Ang-1 expressions in a dose dependent manner