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IL1B — SAA1
Text-mined interactions from Literome
Furlaneto et al., Biochem Biophys Res Commun 2000
:
This study focuses on the
effect of AI,
SAA , and HDL from healthy ( N-HDL ) and acute phase individuals ( AP-HDL ) on the release of TNF-alpha,
IL-1beta , and IL-8 by human blood neutrophils
Yamada et al., Scand J Immunol 2000
(Leukemia, Myeloid) :
These findings are in contrast to the results obtained from hepatoma cell line HepG2, in which
IL-1beta alone could
induce SAA secretion, while dexamethasone supplemented FCS could not
Vallon et al., J Immunol 2001
(Arthritis, Rheumatoid...) :
In the human experimental system,
IL-1beta induced transcription of acute-phase
SAA ( A-SSA ; encoded by SAA1/SAA2 ) in primary chondrocytes
Migita et al., Clin Exp Immunol 2001
(Amyloidosis) :
These findings suggest that activation of monocytes by
IL-1 beta or IFN-gamma hampers the proteolysis of a precursor protein and
leads to a partial degradation of
SAA
Sasaki et al., J Med Microbiol 2001
(Streptococcal Infections) :
Furthermore, a reverse transcription-PCR assay revealed that
SAA 10 microg/ml could
induce mRNA accumulation of tumour necrosis factor-alpha, interleukin
(IL)-1beta and IL-6 as well as iNOS
Ribeiro et al., Mediators Inflamm 2003
:
In a previous study, we reported that
SAA induces the release of tumor necrosis factor-alpha, interleukin
(IL)-1beta and IL-8 from human blood neutrophils
Hagihara et al., Biochem Biophys Res Commun 2004
:
Either IL-6 and IL-1beta or IL-6 and TNFalpha, but not
IL-1beta and TNFalpha,
induced the synergistic induction of
SAA1 and SAA2 genes
Migita et al., Rheumatology (Oxford) 2005
:
IL-1beta is a most potent
inducer of
SAA in normal hepatocytes ... These results indicate that MAPK signalling pathways are critical in
IL-1beta induced hepatic
SAA synthesis
Niemi et al., Biochim Biophys Acta 2006
:
SAA induced dose dependent production of TNF-alpha and
IL-1 beta in HMC-1 cells
Sandri et al., Immunol Lett 2008
:
In previous studies, we demonstrated that
SAA stimulated the production of TNF-alpha,
IL-1beta , IL-8, NO, and ROS by neutrophils and/or mononuclear cells
Balci-Peynircioğlu et al., Clin Exp Rheumatol 2008
(Amyloidosis, Familial...) :
Amyloid development in familial Mediterranean fever ( FMF ) patients is associated with acute phase response and the acute phase reactant
serum amyloid A which is
induced by
IL-1Beta
Poitou et al., J Clin Endocrinol Metab 2009
(Obesity, Morbid) :
IL-1beta , TNF-alpha, and human AT macrophage conditioned medium significantly
induced A-SAA secretion ( from 2.6 to 7.6 fold ) in hMADS cells
Sullivan et al., J Biol Chem 2010
:
Interestingly,
SAA activated smooth muscle cell
IL-1beta mRNA expression, however, blocking IL-1 receptors had no effect on SAA mediated activation of sPLA ( 2 ) expression
Ganapathi et al., J Immunol 1988
:
These results indicate that human
SAA and CRP are
induced in Hep 3B cells by products of activated monocytes but not by
IL-1 beta , TNF-alpha, or some hepatocyte stimulating factor preparations and that a group of heterogeneous mechanisms are involved in the induction of the various human APP
Gabay et al., Clin Exp Immunol 1995
(Carcinoma, Hepatocellular) :
In the hepatoma cell line,
IL-1 beta and/or TNF-alpha
had synergistic effects with IL-6 on the production of CRP and
SAA
Jiang et al., J Immunol 1995
:
Induction of human
serum amyloid A in Hep 3B cells by IL-6 and
IL-1 beta involves both transcriptional and post-transcriptional mechanisms
Steel et al., Biochem J 1993
(Carcinoma, Hepatocellular...) :
These data provide evidence of a paradox with regard to the transcriptional
upregulation of
A-SAA by
IL-1 beta + IL-6 and the relative synthesis of A-SAA protein and suggest a role for post-transcriptional control of A-SAA biosynthesis during the acute phase
Shimetani et al., Nihon Rinsho Meneki Gakkai Kaishi 1997
(Liver Neoplasms, Experimental) :
IL-1 beta induced both CRP and
SAA production but only in the co-presence of IL-6 ... A cytokine IL-6 induced the CRP production in the
presence of
IL-1 beta , but did not affect the constitutive production of
SAA
Lozanski et al., Biochem J 1997
(Carcinoma, Hepatocellular) :
The ability of C2 and C6 to potentiate the effects of cytokines suggests that the sphingomyelin-ceramide pathway participates in
induction of CRP and
SAA by
IL-6+IL-1beta under these experimental conditions, most likely by transducing the effects of IL-1beta