Gene interactions and pathways from curated databases and text-mining

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IL1B — SAA1

Text-mined interactions from Literome

Furlaneto et al., Biochem Biophys Res Commun 2000 : This study focuses on the effect of AI, SAA , and HDL from healthy ( N-HDL ) and acute phase individuals ( AP-HDL ) on the release of TNF-alpha, IL-1beta , and IL-8 by human blood neutrophils
Yamada et al., Scand J Immunol 2000 (Leukemia, Myeloid) : These findings are in contrast to the results obtained from hepatoma cell line HepG2, in which IL-1beta alone could induce SAA secretion, while dexamethasone supplemented FCS could not
Vallon et al., J Immunol 2001 (Arthritis, Rheumatoid...) : In the human experimental system, IL-1beta induced transcription of acute-phase SAA ( A-SSA ; encoded by SAA1/SAA2 ) in primary chondrocytes
Migita et al., Clin Exp Immunol 2001 (Amyloidosis) : These findings suggest that activation of monocytes by IL-1 beta or IFN-gamma hampers the proteolysis of a precursor protein and leads to a partial degradation of SAA
Sasaki et al., J Med Microbiol 2001 (Streptococcal Infections) : Furthermore, a reverse transcription-PCR assay revealed that SAA 10 microg/ml could induce mRNA accumulation of tumour necrosis factor-alpha, interleukin (IL)-1beta and IL-6 as well as iNOS
Ribeiro et al., Mediators Inflamm 2003 : In a previous study, we reported that SAA induces the release of tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-8 from human blood neutrophils
Hagihara et al., Biochem Biophys Res Commun 2004 : Either IL-6 and IL-1beta or IL-6 and TNFalpha, but not IL-1beta and TNFalpha, induced the synergistic induction of SAA1 and SAA2 genes
Migita et al., Rheumatology (Oxford) 2005 : IL-1beta is a most potent inducer of SAA in normal hepatocytes ... These results indicate that MAPK signalling pathways are critical in IL-1beta induced hepatic SAA synthesis
Niemi et al., Biochim Biophys Acta 2006 : SAA induced dose dependent production of TNF-alpha and IL-1 beta in HMC-1 cells
Sandri et al., Immunol Lett 2008 : In previous studies, we demonstrated that SAA stimulated the production of TNF-alpha, IL-1beta , IL-8, NO, and ROS by neutrophils and/or mononuclear cells
Balci-Peynircioğlu et al., Clin Exp Rheumatol 2008 (Amyloidosis, Familial...) : Amyloid development in familial Mediterranean fever ( FMF ) patients is associated with acute phase response and the acute phase reactant serum amyloid A which is induced by IL-1Beta
Poitou et al., J Clin Endocrinol Metab 2009 (Obesity, Morbid) : IL-1beta , TNF-alpha, and human AT macrophage conditioned medium significantly induced A-SAA secretion ( from 2.6 to 7.6 fold ) in hMADS cells
Sullivan et al., J Biol Chem 2010 : Interestingly, SAA activated smooth muscle cell IL-1beta mRNA expression, however, blocking IL-1 receptors had no effect on SAA mediated activation of sPLA ( 2 ) expression
Ganapathi et al., J Immunol 1988 : These results indicate that human SAA and CRP are induced in Hep 3B cells by products of activated monocytes but not by IL-1 beta , TNF-alpha, or some hepatocyte stimulating factor preparations and that a group of heterogeneous mechanisms are involved in the induction of the various human APP
Gabay et al., Clin Exp Immunol 1995 (Carcinoma, Hepatocellular) : In the hepatoma cell line, IL-1 beta and/or TNF-alpha had synergistic effects with IL-6 on the production of CRP and SAA
Jiang et al., J Immunol 1995 : Induction of human serum amyloid A in Hep 3B cells by IL-6 and IL-1 beta involves both transcriptional and post-transcriptional mechanisms
Steel et al., Biochem J 1993 (Carcinoma, Hepatocellular...) : These data provide evidence of a paradox with regard to the transcriptional upregulation of A-SAA by IL-1 beta + IL-6 and the relative synthesis of A-SAA protein and suggest a role for post-transcriptional control of A-SAA biosynthesis during the acute phase
Shimetani et al., Nihon Rinsho Meneki Gakkai Kaishi 1997 (Liver Neoplasms, Experimental) : IL-1 beta induced both CRP and SAA production but only in the co-presence of IL-6 ... A cytokine IL-6 induced the CRP production in the presence of IL-1 beta , but did not affect the constitutive production of SAA
Lozanski et al., Biochem J 1997 (Carcinoma, Hepatocellular) : The ability of C2 and C6 to potentiate the effects of cytokines suggests that the sphingomyelin-ceramide pathway participates in induction of CRP and SAA by IL-6+IL-1beta under these experimental conditions, most likely by transducing the effects of IL-1beta