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IL1B — WNK1

Text-mined interactions from Literome

Pizzi et al., J Biol Chem 2002 : Moreover, IL-1beta activated the p50, p65 , and c-Rel subunits of NF-kappaB/Rel, whereas glutamate activated only the p50 and p65 proteins
Gan et al., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2003 (Colitis, Ulcerative) : The results showed that NF-kappa B p65 antisense oligonucleotides resulted in down-regulation of NF-kappa B p65 expression, blocked the expression of IL-1 beta mRNA and IL-8 mRNA, and strikingly reduced the production of IL-1 beta and IL-8, and these effects were greater than those of dexamethasone in cultured LPMC from patients with UC ( P < 0.05 )
Chen et al., Invest Ophthalmol Vis Sci 2005 : IL-1beta , TNFalpha, and VEGF ( 165 ) induced nuclear translocation and binding of p65 and p50 NF-kappaB isoforms to the VCAM-1 promoter
Wei et al., Mol Pharmacol 2006 : In addition, fluvastatin increased IL-1beta induced p65 nuclear translocation and nuclear factor kappaB (NF-kappaB) activity, although it inhibited those induced by LPS
Wehkamp et al., J Invest Dermatol 2006 : Transcription factor ELISAs indicated that the NF-kappaB heterodimer p50-p65 binds to all three NF-kappaB sites in the hBD-2 promoter upon stimulation of primary keratinocytes with IL-1beta and PA
Issa et al., Am J Physiol Lung Cell Mol Physiol 2006 (MAP Kinase Signaling System) : AS-602868 but not PD-98059 or SP-600125 inhibited p65 DNA binding induced by IL-1beta and TNF-alpha
Jun et al., Inflamm Bowel Dis 2006 (Body Weight...) : Pretreatment of human epithelial HT-29 cells with gliotoxin significantly blocked the I-kappaB degradation and NF-kappaB p65 nuclear translocation induced by tumor necrosis factor-alpha or IL-1beta ; these were parallel with the inhibition of IL-8 secretion and intercellular adhesion molecule-1 expression in the same cells
Morello et al., J Immunol 2006 : IL-1beta and TNF-alpha rapidly activated p50 and p65 , but not C-Rel, RelB, or p52, and both IL-1beta- and TNF-alpha stimulated A2AR expression was inhibited by the IkappaB kinase 2 inhibitor AS602868 in a concentration dependent manner
Kitaoka et al., Brain Res 2007 : Western blot analysis showed elevated levels of retinal IL-1beta protein 12 h after intravitreal NMDA injection and this elevation was significantly inhibited by NF-kappaB p65 AS ODN
Niesporek et al., Verh Dtsch Ges Pathol 2007 (Ovarian Neoplasms) : DNA binding avtivity as well as COX-2 mRNA and protein expression were strongly inducible by IL-1beta treatment in OVCAR-3 cells, while p65 siRNA inhibited IL-1beta dependent p65 activity ( p = 0.037 ) as well as COX-2 expression on the mRNA ( p < 0.03 ) and on the protein level
Callister et al., Br J Pharmacol 2008 : PMX464 inhibited IL-1beta induced NF-kappaB DNA binding, nuclear translocation of NF-kappaB p65 subunit and factors involved in NF-kappaB activation ; specifically, IkappaBalpha degradation, IkappaB phosphorylation and IkappaB kinase (IKK) activity in A549
Kimura et al., Invest Ophthalmol Vis Sci 2009 : IL-1beta induced the phosphorylation and downregulation of IkappaB-alpha as well as the translocation of p65 to the nucleus
Hu et al., Am J Physiol Cell Physiol 2009 : Inhibition of GSK3beta abolished IL-1beta induced phosphorylation of IKK2/p65
Torigoshi et al., Clin Exp Rheumatol 2009 (Arthritis, Rheumatoid) : Furthermore, tacrolimus also decreased the IL-1Beta induced DNA binding activity of p65 , a subunit of NF-KappaB, in the presence of 10-9 M of Dex
Yang et al., J Cell Physiol 2010 (Arthritis, Rheumatoid) : IL-1beta induced ICAM-1 expression, extracellular signal regulated kinase ( ERK ) and c-Jun-N-terminal kinase (JNK) phosphorylation, AP-1 activation, and nuclear factor-kappaB (NF-kappaB) p65 translocation were attenuated by the inhibitors of MEK1/2 ( U0126 ), JNK ( SP600125 ), AP-1 ( tanshinone IIA ), and NF-kappaB ( helenalin ) or transfection with respective short hairpin RNA plasmids
Crofford et al., Arthritis Rheum 1997 (Arthritis, Rheumatoid) : IL-1 beta rapidly stimulated the translocation of the p65 , p50, and c-rel NF-kappa B subunits from the cytoplasm to the nucleus
Parry et al., Arterioscler Thromb Vasc Biol 1998 : In contrast to TPCK, which blocked NF-kappaB translocation to the nucleus, norLeu had no effect on NF-kappaB nuclear translocation or IL-1beta induced phosphorylation of p65