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BMP2 — PRKAR2B

Text-mined interactions from Literome

Gupta et al., J Biol Chem 1999 : To determine mechanisms underlying the interdependence of BMP signaling and PKA activity, we examined the effect of PKA on the known signaling events in the BMP-2 dependent Smad1 signaling pathway and the effect of BMP-2 on PKA activity ... In contrast, BMP-2 increased endogenous PKA activity and induced phosphorylation of the PKA effector, cAMP-response element binding protein, in a PKA dependent manner ... In contrast, BMP-2 increased endogenous PKA activity and induced phosphorylation of the PKA effector, cAMP-response element binding protein, in a PKA dependent manner ... We conclude that BMP-2 induces activation of PKA and that PKA regulates the effects of BMPs on collecting duct morphogenesis without activating the known signaling events in the BMP-2 dependent Smad1 signaling pathway
Tee et al., Dev Biol 2010 : We also found that BMP2 was higher in unbudded regions of the GDNF stimulated WD. Treatment of isolated WDs with BMP2 suppressed budding and resulted in a 3-fold increase in PKA activity
Lee et al., J Cell Physiol 1997 : We showed the following points : 1 ) in micromass cultures, activation of PKA enhances chondrogenesis and increases the phosphorylation of CREB; 2 ) BMP-2, a chondrogenic stimulator, increases PKA activity and the level of phosphorylated CREB ( P-CREB ) ; 3 ) H8, a PKA inhibitor, inhibits chondrogenesis ; 4 ) the chondrogenic activities of BMP-2 and cAMP are suppressed by H8 ; and 5 ) long-term TPA treatment ( a protein kinase C ( PKC ) modulator ) inhibits chondrogenesis and decreases the levels of CREB and P-CREB