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ATP5O — LEP

Text-mined interactions from Literome

Bełtowski et al., Med Sci Monit 2002 (Obesity) : By contrast, leptin had no effect on either cortical Na+, K+-ATPase or the ouabain-resistant fraction of ATPase ... In obese rats, leptin increased urine output by only 29.1 % and natriuresis by 28.9 %, and had no significant effect on medullary Na+, K+-ATPase
Bełtowski et al., Pol J Pharmacol 2004 (Hypertension) : In contrast, leptin had no effect on either cortical or medullary ouabain-sensitive H ( + ), K ( + ) -ATPase
Bełtowski et al., J Physiol Pharmacol 2004 : We examined the effect of leptin on renal function and renal Na ( + ), K ( + ) -ATPase and ouabain-sensitive H ( + ), K ( + ) -ATPase activities in the rat ... The effect of leptin on Na ( + ), K ( + ) -ATPase activity was abolished by actin depolymerizing agents, cytochalazin D and latrunculin B, and by phosphatidylinositol 3-kinase (PI3K) inhibitors, wortmannin and LY294002
Marciniak et al., Acta biochimica Polonica 2005 : We investigated the effect of leptin , administered for different time periods, on renal Na ( + ), K ( + ) -ATPase activity in the rat ... The effect of leptin on renal Na ( + ), K ( + ) -ATPase and urinary H ( 2 ) O ( 2 ) was augmented by a superoxide dismutase mimetic, tempol, and was abolished by catalase ... Inhibitors of extracellular signal regulated kinases ( ERKs ), PD98059 or U0126, prevented Na ( + ), K ( + ) -ATPase stimulation by leptin and H ( 2 ) O ( 2 )
Bełtowski et al., Peptides 2006 : We examined the mechanism through which leptin increases Na ( + ), K ( + ) -ATPase activity in the rat kidney ... Leptin ( 1mug/kgmin ) increased Na ( + ), K ( + ) -ATPase activity after 3h of infusion, which was accompanied by the increase in urinary H ( 2 ) O ( 2 ) excretion and phosphorylation level of extracellular signal regulated kinase ( ERK ) ... The effect of leptin on ERK and Na ( + ), K ( + ) -ATPase was abolished by catalase, specific inhibitors of epidermal growth factor (EGF) receptor, AG1478 and PD158780, as well as by ERK inhibitor, PD98059, and was mimicked by both exogenous H ( 2 ) O ( 2 ) and EGF ... We conclude that leptin induced stimulation of renal Na ( + ), K ( + ) -ATPase involves H ( 2 ) O ( 2 ) generation, Src kinase, transactivation of the EGF receptor, and stimulation of ERK
Marciniak et al., Clin Exp Pharmacol Physiol 2006 : Time dependent transition from H ( 2 ) O ( 2 ) -extracellular signal regulated kinase- to O ( 2 ) -nitric oxide dependent mechanisms in the stimulatory effect of leptin on renal Na+/K+/-ATPase in the rat ... Leptin ( 1 microg/min per kg ) had a time dependent effect on renal Na ( + ) /K ( + ) -ATPase in both the control and hyperleptinaemic groups ... 7. The results suggest that the acute stimulatory effect of leptin on renal Na ( + ) /K ( + ) -ATPase is mediated by divergent mechanisms depending on the chronic leptin level ( i.e. by H ( 2 ) O ( 2 ) -dependent stimulation of ERK in normoleptinaemic animals and by superoxide dependent impairment of the nitric oxide-cGMP pathway in hyperleptinaemic rats )
Bełtowski et al., Clin Exp Hypertens 2007 (Disease Models, Animal...) : Regulation of renal ouabain-resistant Na+-ATPase by leptin , nitric oxide, reactive oxygen species, and cyclic nucleotides : implications for obesity associated hypertension ... This study examined the effect of leptin on renal ouabain-resistant Na ( + ) -ATPase , which drives the reabsorption of about 10 % of sodium transported in the proximal tubule
Wójcicka et al., Life Sci 2008 (Disease Models, Animal...) : In addition, leptin reduced urinary Na ( + ) excretion and increased renal Na ( + ), K ( + ) -ATPase activity, and these effects were abolished on days 4 and 8 by PD98059 and tempol, respectively ... NADPH oxidase inhibitor, apocynin, prevented leptin 's effect on BP, ERK, Na ( + ), K ( + ) -ATPase/Na ( + ) excretion and NO formation at all time points
Jamroz-Wiśniewska et al., Biochem Pharmacol 2008 (Hypertension) : The effects of leptin on renal Na+, K+-ATPase , natriuresis and blood pressure were abolished by NADPH oxidase inhibitor, apocynin, Src kinase inhibitor, PP2, EGF receptor inhibitor, AG1478, protein farnesyltransferase inhibitor, manumycin A, and ERK inhibitor, PD98059
Bełtowski et al., Peptides 2010 (Obesity) : In both control and hyperleptinemic groups the effect of leptin on Na ( + ) excretion and renal Na ( + ), K ( + ) -ATPase was abolished by phosphoinositide 3-kinase (PI3K) inhibitor, wortmannin, but not by protein kinase B/Akt inhibitor, triciribine,
Kumar et al., Indian J Pharmacol 2012 (Disease Models, Animal...) : Further, mean arterial blood pressure, heart rate, serum leptin , insulin, LDH, LDL-C, total cholesterol, triglycerides, and apolipoprotein-B levels were enhanced significantly, whereas serum HDL-C, apoliporotein-A1 levels, and cardiac Na ( + ) K ( + ) ATPase , antioxidant enzymes levels were significantly decreased