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RGCC — SMAD3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Guo et al., Am J Physiol Cell Physiol 2011
:
Coexpression of RGC-32 and
Smad3 , but not Smad2,
induces a higher mesenchymal marker a-smooth muscle actin ( a-SMA ) protein expression as compared with RGC-32 or Smad3 alone, while knockdown of Smad3 using short hairpin interfering RNA blocks
RGC-32 induced a-SMA expression
Huang et al., Am J Physiol Cell Physiol 2011
:
Functionally, Smad2, but not
Smad3 ,
activated RGC-32 promoter
Li et al., J Biol Chem 2011
(Disease Models, Animal...) :
Mechanistically,
RGC-32 interacts with Smad3 and
enhances Smad3 binding to the Smad binding element in a-SMA promoter as demonstrated by DNA affinity assay