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HDAC1 — NOTCH4
Text-mined interactions from Literome
Hughes et al., Cancer Treat Res 2009
(Bone Neoplasms...) :
Further, exposure to valproic acid at therapeutic concentrations induced expression of Notch genes and caused a 250-fold increase in invasiveness for non-invasive cell lines, but had no discernible effect on those lines that expressed high levels of Notch without valproic acid treatment, suggesting a
role for
HDAC in regulating
Notch pathway expression in osteosarcoma
Mulligan et al., Mol Cell 2011
:
A
SIRT1-LSD1 corepressor complex
regulates Notch target gene expression and development
Tang et al., Journal of the American Heart Association 2012
:
However, inhibition of
HDAC activity did not
suppress Notch activation of the HRT target genes ... Although CBF-1 mediated
Notch signaling was
increased by
HDAC inhibition in human SMCs and in a C3H10T1/2 model, SMC differentiation was inhibited in both cases ... Although CBF-1 mediated
Notch signaling is not
suppressed by
HDAC inhibition, HDAC activity is required for Notch differentiation signals through mitogen activated protein kinase and PI3K pathways in SMCs. ( J Am Heart Assoc. 2012 ; 1 : e000901 doi : 10.1161/JAHA.112.000901 )
Zhao et al., Neoplasia (New York, N.Y.) 2013
:
We showed that
hD1R could bind to ECs specifically through its RGD motif and effectively
triggered Notch signaling in ECs