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LINGO1 — RHOA
Pathways - manually collected, often from reviews:
-
NCI Pathway Database p75(NTR)-mediated signaling:
MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1)
→
RHOA/GTP complex (RHOA)
(modification, collaborate)
Wang et al., Nature 2002, Yamashita et al., Nat Neurosci 2003, Mi et al., Nat Neurosci 2004
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1)
→
RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA)
(modification, collaborate)
Wang et al., Nature 2002, Yamashita et al., Nat Neurosci 2003, Mi et al., Nat Neurosci 2004
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
RHOA/GTP complex (RHOA)
→
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI complex (RTN4R-NGFR-LINGO1-ARHGDIA)
(modification, collaborate)
Wang et al., Nature 2002, Yamashita et al., Nat Neurosci 2003, Mi et al., Nat Neurosci 2004
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI complex (RTN4R-NGFR-LINGO1-ARHGDIA)
→
RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA)
(modification, collaborate)
Wang et al., Nature 2002, Yamashita et al., Nat Neurosci 2003, Mi et al., Nat Neurosci 2004
Evidence: mutant phenotype, assay, physical interaction, other species
Text-mined interactions from Literome
Mi et al., Nat Neurosci 2005
:
Conversely, overexpression of
LINGO-1 leads to activation of
RhoA and inhibition of oligodendrocyte differentiation and myelination
Jepson et al., J Biol Chem 2012
(Multiple Sclerosis) :
Finally, we observed that soluble
LINGO-1 could
activate RhoA in OPCs
Mi et al., CNS Drugs 2013
:
LINGO-1 negatively
regulates oligodendrocyte differentiation and myelination, neuronal survival and axonal regeneration by activating
ras homolog gene family member A (RhoA) and inhibiting protein kinase B ( Akt ) phosphorylation signalling pathways