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NOX5 — TGFB1
Text-mined interactions from Literome
Grewal et al., Am J Physiol 1999
(Fibrosis) :
TGF-beta1 mRNA induction was also
blocked by diphenyleneiodonium and 4- ( 2-aminoethyl ) -benzenesulfonyl fluoride, which inhibit
NAD ( P ) H oxidase , a source of oxidants
Wolf et al., FEBS Lett 2001
:
Our data provide evidence that
TGF-beta1 transcription is negatively
regulated in MCT cells under basal conditions by
NADP ( H ) oxidase mediated oxygen radicals
Rashed et al., Am J Nephrol 2004
:
This is the first study to demonstrate that the mechanism of oxalate induced free radical production in renal tubular epithelial cells is through the
activation of
NAD ( P ) H oxidase via cytokine
TGF-beta1 induction
Mata-Greenwood et al., Am J Physiol Lung Cell Mol Physiol 2005
:
Therefore, our results indicate that cyclic stretch upregulates VEGF expression via the
TGF-beta1 dependent activation of
NAD ( P ) H oxidase and increased generation of ROS
Cucoranu et al., Circ Res 2005
(Fibrosis) :
Depletion of Nox4 but not
Nox5 inhibits baseline and
TGF-beta1 stimulation of Smad 2/3 phosphorylation by 75+/-5 % and 68+/-3 %, respectively ( n=7, P < 0.0001 )
Sturrock et al., Am J Physiol Lung Cell Mol Physiol 2006
:
Transforming growth factor-beta1 induces Nox4
NAD ( P ) H oxidase and reactive oxygen species dependent proliferation in human pulmonary artery smooth muscle cells
Zhan et al., Hepatology 2006
(Disease Models, Animal...) :
NADPH oxidase activation resulted in upregulation of procollagen alpha1 ( I ) ; in contrast,
TGF-beta1 expression was
independent of
NADPH oxidase activation
Murillo et al., Biochem J 2007
:
Activation of
NADPH oxidase by
transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB dependent mechanism
Qian et al., J Immunol 2008
(Inflammation) :
Moreover, we demonstrate that
TGF-beta1 inhibited LPS induced
NADPH oxidase ( PHOX ) subunit p47phox translocation from the cytosol to the membrane in microglia within 10 min. Mechanistic studies show that TGF-beta1 fails to protect dopaminergic neurons in cultures from PHOX knockout mice, and significantly reduced LPS induced translocation of the PHOX cytosolic subunit p47phox to the cell membrane
Djamali et al., Am J Transplant 2009
(Fibrosis...) :
Cyclosporine A,
TGF-beta1 and angiotensin II
increased Nox-2 mRNA levels 2- to 7-fold in vitro ( NRK52E cells )
Vural et al., Int Immunopharmacol 2009
(Hashimoto Disease) :
Plasma
TGF-beta1 and VEGF were decreased, and
NOx increased in HT patients in comparison with controls
Zhang et al., Nephrology (Carlton) 2009
:
TGF-beta1 differentially
regulates the expression of
NAD ( P ) H oxidase subunits and mediates MCP-1 and IL-6 expression in rat renal tubular cells via the NAD ( P ) H oxidase/p67phox dependent mechanism
Bondi et al., J Am Soc Nephrol 2010
:
In addition,
TGF-beta1 increased both the activity of NADPH oxidase and expression of
Nox2 and Nox4, homologs of the NAD ( P ) H oxidase family, indicating that this growth factor induces production of ROS ... Small interfering RNA targeted against Nox4 markedly inhibited
TGF-beta1 induced stimulation of
NADPH oxidase activity and reduced alpha-SMA and Fn-ED-A expression ... Inhibition of
TGF-beta1 receptor 1
blocked Smad3 phosphorylation ; reduced TGF-beta1 enhanced
NADPH oxidase activity ; and decreased expression of Nox4, alpha-SMA, and Fn-ED-A
Buday et al., Am J Physiol Heart Circ Physiol 2010
(Atherosclerosis...) :
Our results demonstrate that elevated circulating
TGF-beta(1) causes endothelial dysfunction through
NOX activation induced oxidative stress, accelerating atherosclerosis and hypertension in apoE ( -/- ) mice