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APC — CD4
Text-mined interactions from Literome
Dembic et al., Proc Natl Acad Sci U S A 2000
(Multiple Myeloma) :
The
APC could
stimulate Id-specific naive TCR-TG, short-term polarized TCR-TG, and cloned
CD4 ( + ) T cells to proliferate and produce cytokines in vitro
Richards et al., Eur J Immunol 2000
:
This study demonstrates, more critically, that when
APC are present, glucocorticoids
induce CD4 and CD8 T cell populations synthesizing high levels of IL-10, but greatly reduced amounts of disease promoting IL-4 and IL-5
Qi et al., J Immunol 2000
(Sarcoma, Experimental) :
Because class II ( + ) tumor cells are effective
APC in vivo and probably present novel tumor Ag epitopes not presented by host derived APC, their inclusion in cancer vaccines may
enhance activation of tumor-reactive
CD4 ( + ) T cells
Suciu-Foca et al., Transpl Immunol 2003
:
Tolerized
APC , which expresses high ILT3 and ILT4,
trigger the generation of antigen-specific
CD4 ( + ) T ( R ) propagating antigen-specific suppression
Parker et al., Transplantation 1992
:
In vitro proliferation studies demonstrated that
CD4+ but not CD8+ T cells of the PVG strain responded in a recipient
APC dependent manner to the peptide, whereas the BN strain ( which showed no antibody response to this peptide ) gave no T cell proliferation
Gelman et al., J Immunol 2004
:
APC TLR engagement indirectly
enhances activated
CD4 ( + ) T cell proliferation, differentiation, and survival by promoting the up-regulation of costimulatory molecules and the secretion of proinflammatory cytokines
Fazal et al., Biochim Biophys Acta 2006
(Burns...) :
This altered
APC : CD4+ T cell interaction
leads to suppressed
CD4+ T cell activation of healthy animals
Chang et al., Cytotherapy 2007
(Glioma...) :
Background The role of co-stimulation in
CD4+ T cell
activation by professional
APC is well established, while less is known of the role co-stimulation plays when CD4+ T cells interact directly with tumor cells
Manirarora et al., PloS one 2008
(Diabetes Mellitus) :
APC activation
restores functional
CD4 ( + ) CD25 ( + ) regulatory T cells in NOD mice that can prevent diabetes development
Moran et al., Inflamm Bowel Dis 2009
(Bifidobacteriales Infections...) :
Bacterial antigen-specific
CD4 ( + ) mesenteric lymph node (MLN) T-cell recall responses were measured in
response to
antigen presenting cells (APC) pulsed with bacterial lysates
Shih et al., Eur J Immunol 2009
(Inflammatory Bowel Diseases) :
Microbial induction of TL1A production by human
APC potentiated
CD4 ( + ) T-cell effector function by augmenting IFN-gamma production
Schiechl et al., Am J Transplant 2013
(Disease Models, Animal) :
We examined the
effect of TREM-1 ( + )
antigen presenting cells (APC) on alloreactive
CD4 ( + ) lymphocytes
Schnyder et al., J Clin Invest 1997
(Cell Transformation, Viral...) :
The
stimulation of four
CD4 ( + ) and two CD8 ( + ) sulfamethoxazole-specific T cell clones by different
antigen presenting cells (APC) was measured both by proliferation and cytolytic assays
Mannie et al., Cell Immunol 1998
:
In this study, single positive CD4+ and double negative ( DN ) ( CD4-CD8- ) T-helper cells specific for the 55-69 or 72-86 sequence of guinea pig ( GP ) myelin basic protein ( GPMBP ) were used to study
CD4 regulation of
T-APC activity