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EPHB2 — KSR1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yan et al., Cancer Res 2001
(MAP Kinase Signaling System) :
To determine the
role of
KSR in TNF-alpha induced
ERK1/ERK2 activation, we studied young adult mouse colon cells expressing a dominant negative, kinase-inactive ( ki ) KSR
Razidlo et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
Kinase suppressor of Ras (KSR) is a molecular scaffold that interacts with the components of the Raf/MEK/ERK kinase cascade and positively
regulates ERK signaling
Kortum et al., Mol Cell Biol 2005
:
Elevated levels of
KSR1 expression, previously shown to enhance cell proliferation,
promote high, sustained
ERK activation that phosphorylates and inhibits peroxisome proliferator activated receptor gamma, inhibiting adipogenesis
Fusello et al., J Immunol 2006
(Arthritis) :
The MAPK scaffold
kinase suppressor of Ras is
involved in
ERK activation by stress and proinflammatory cytokines and induction of arthritis ... Although the scaffold kinase suppressor of Ras (KSR)1 is required for efficient Erk activation by mitogenic stimuli, the
role of
KSR1 in
ERK activation by inflammatory and stress stimuli is unknown ... In this study, we examined the
effects of
KSR deficiency on
ERK activation by stress stimuli and show that ERK activation by TNF, IL-1, and sorbitol is attenuated in the absence of KSR1 ... Thus,
KSR plays a role in
ERK activation during inflammatory and stress responses both in vitro and in vivo
Ritt et al., Curr Biol 2007
(MAP Kinase Signaling System) :
Moreover, we find that the
KSR1/CK2 interaction is
required for KSR1 to maximally facilitate
ERK cascade signaling and contributes to the regulation of Raf kinase activity
Szatmari et al., J Neurosci 2007
:
Also, overexpression of KSR1 enhanced BDNF protection against CPT. Therefore,
KSR1 is specifically
involved in antigenotoxic activation of
ERK1/2 by BDNF ... To test whether
KSR1 contributes to
ERK1/2 activation by other neuroprotective stimuli, we used a cAMP elevating drug, forskolin ... Hence,
KSR1 is
critical for the antiapoptotic activation of
ERK1/2 by BDNF or cAMP/PKA signaling
Kraft et al., J Biol Chem 2008
:
Overexpression of the mutant
KSR1 in HIRcB cells
inhibited insulin dependent MEK and
ERK phosphorylation
Casar et al., Mol Cell Biol 2009
:
As such, we show that for cPLA(2) activation,
ERK1/2 activated at lipid rafts interact with
KSR1 , whereas ERK1/2 activated at the endoplasmic reticulum utilize Sef-1
Razidlo et al., J Biol Chem 2009
(MAP Kinase Signaling System) :
KSR1 is
required for maximal
ERK activation induced by growth factors and by some cytotoxic agents ... We show here that
KSR1 is also
required for maximal
ERK activation induced by UV light, ionizing radiation, or the DNA interstrand cross linking agent mitomycin C ( MMC ) ... These data reveal a specific role for the molecular scaffold KSR1 and
KSR1 mediated
ERK signaling in the cellular response to DNA interstrand cross-links
McKay et al., Proc Natl Acad Sci U S A 2009
:
Together, these findings provide unique insight into the signaling dynamics of the KSR1 scaffold and reveal that through regulated interactions with Raf and
ERK ,
KSR1 acts to both potentiate and attenuate ERK cascade activation, thus regulating the intensity and duration of ERK cascade signaling emanating from the plasma membrane during growth factor signaling
Canal et al., FASEB J 2011
:
Our findings, therefore, suggest that feedback phosphorylation of the scaffold protein
KSR1 prevents excessive
ERK1/2 signaling in the postsynaptic compartment and thus contributes to maintaining physiological levels of synaptic excitability
Li et al., Cell Physiol Biochem 2012
(Acute Lung Injury...) :
Ksr1 also
enhances Raf-1/MEK/ERK signaling and is involved in a variety of cellular responses, including cell differentiation, proliferation, and apoptosis ... Taken together, these findings indicate that
Ksr1 plays a dispensable role in LPS induced
ERK activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS model
Le Borgne et al., PloS one 2013
(Listeriosis...) :
Absence of
kinase suppressor of Ras 1 (KSR1) , a scaffold protein of the ERK signaling pathway, or
inhibition of
ERK resulted in decreased mTORC1 activity following T cell activation