◀ Back to CDK3

CDK3 — CDK4

Pathways - manually collected, often from reviews:

• BioCarta estrogen responsive protein efp controls cell cycle and breast tumors growth: CDKs/Cyclin B1/2/14-3-3-sigma/ubiquitin complex (CDK2_CDK3_CDK6_CDK7_CDK5_CDK4_CDC2_CDK8-CCNB2_CCNB1-SFN) → CDKs/Cyclin B1/2/14-3-3-sigma complex (CDK2_CDK3_CDK6_CDK7_CDK5_CDK4_CDC2_CDK8-CCNB2_CCNB1-SFN) (protein ubiquitination, collaborate)
  
• BioCarta estrogen responsive protein efp controls cell cycle and breast tumors growth: CDKs/Cyclin B1/2 complex (CDK2_CDK3_CDK6_CDK7_CDK5_CDK4_CDC2_CDK8-CCNB2_CCNB1) → CDKs/Cyclin B1/2/14-3-3-sigma complex (CDK2_CDK3_CDK6_CDK7_CDK5_CDK4_CDC2_CDK8-CCNB2_CCNB1-SFN) (modification, collaborate)
  
• BioCarta estrogen responsive protein efp controls cell cycle and breast tumors growth: CDKs/Cyclin B1/2/14-3-3-sigma/ubiquitin complex (CDK2_CDK3_CDK6_CDK7_CDK5_CDK4_CDC2_CDK8-CCNB2_CCNB1-SFN) → CDKs/Cyclin B1/2 complex (CDK2_CDK3_CDK6_CDK7_CDK5_CDK4_CDC2_CDK8-CCNB2_CCNB1) (degradation, collaborate)
  

Text-mined interactions from Literome

González et al., J Biol Chem 2003 : We show in this work that the inhibition of Cdk4 ( 6 ) in Rb(-/-) 3T3 cells enhances the accumulation of the p27 ( kip1 ) cyclin dependent kinase inhibitor when these cells are induced into quiescence
Lu et al., J Pharm Pharmacol 2007 : AOA-GMe induced cell cycle arrest in G0/G1 and blocked G1-S transition, which correlated well with marked decreases in levels of cyclin D, cyclin dependent kinase CDK4 and phosphorylated retinoblastoma protein, and increases in the cyclin dependent kinase inhibitor p15
Kang et al., Apoptosis 2012 : Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1, cyclin A and CDK4 , and the induction of p21 and p27, a cyclin dependent kinase inhibitor