◀ Back to NFKB1
NFKB1 — VCAM1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Fujita et al., Nihon rinsho. Japanese journal of clinical medicine 1999
(Diabetic Angiopathies...) :
In macroangiopathy, AGE plays an important role in atherogesis through
NF-kappa B activation, that
induces VCAM-1 and MCP-1
Ishizuka et al., Eur J Pharmacol 1999
:
These findings suggest that the synergistic enhancement of
VCAM-1 expression by TNF-alpha and endothelin ET ( B ) receptor stimulation may be
augmented by the induction of
NF-kappaB binding activity in human vascular endothelial cells
Mohan et al., Am J Physiol 1999
:
Here we investigate the hypothesis that low shear induced activation of
NF-kappaB is
responsible for enhanced expression of vascular cell adhesion molecule (
VCAM-1 ) resulting in augmented endothelial cell-monocyte ( EC-Mn ) adhesion and that this activation is dependent on intracellular oxidant activity ... These data suggest that
NF-kappaB plays a key role in low shear induced
VCAM-1 expression and that pathways mediating low shear- and cytokine induced EC-Mn adhesion may be differentially regulated
Marx et al., Circulation 1999
(Arteriosclerosis) :
Transient transfection of deletional VCAM-1 promoter constructs and electrophoretic mobility shift assays suggest that fenofibrate
inhibits VCAM-1 transcription in part by inhibiting
NF-kappaB
Wright et al., J Cell Physiol 1999
:
These data suggest that a significant increase in nuclear
NF-kappaB levels is not necessary or
sufficient for
VCAM-1 upregulation in HASMCs and does not determine the relative sensitivity to inhibition of gene expression by PDTC
Li et al., J Immunol 2000
:
NF-kappa B regulates
VCAM-1 expression on fibroblast-like synoviocytes ... These results indicate that
NF-kappa B mediates TNF-alpha induced
VCAM-1 expression on mFLS
Tummala et al., J Mol Cell Cardiol 2000
:
These data suggest that flavin binding proteins such as NADH/NADPH oxidase can
regulate VCAM-1 gene expression independent of
NF- kappa B
De Caterina et al., Arterioscler Thromb Vasc Biol 2001
:
To determine whether nuclear factor (NF)-kappaB is necessary to confer endothelial cell responsiveness to interferon (INF)-gamma in terms of vascular cell adhesion molecule (VCAM)-1 expression and leukocyte adhesion, human endothelial cells were treated with IFN-gamma in the presence of low concentrations ( LCs ) of interleukin (IL)-1alpha ( < /=100 pg/mL ), which activates
NF-kappaB but does not
induce VCAM-1 expression
Viita et al., Antioxid Redox Signal 1999
(Arteriosclerosis) :
High expression of human 15-lipoxygenase induces
NF-kappaB mediated expression of
vascular cell adhesion molecule 1 , intercellular adhesion molecule 1, and T-cell adhesion on human endothelial cells ... These cells were used to study the effects of 15-LO on the expression of
vascular cell adhesion molecule 1 ( VCAM-1 ) and intercellular adhesion molecule 1 ( ICAM-1 ),
activation of
nuclear factor kappa B (NF-kappaB) , and T-cell adhesion on endothelial cells ...
NF-kappaB activation was greatly potentiated by increased 15-LO activity in the stably transduced cells, and both
VCAM-1 and ICAM-1 were significantly
induced in these cells in response to tumor necrosis factor-alpha (TNF-alpha) and phorbol 12-myristate 13-acetate ( PMA ) stimulation, as studied by flow cytometry
Hong et al., Biochem Biophys Res Commun 2001
(Arteriosclerosis...) :
Our results suggest that the down-regulation of
VCAM-1 expression by hematein may in part be
due to the inhibition of
NF-kappaB dependent gene expression
Morel et al., J Biol Chem 2001
(Arthritis, Rheumatoid) :
IL-18
requires NF kappa B as well as PI 3-kinase to induce
VCAM-1 on RA synovial fibroblasts, suggesting that there may be two distinct pathways in IL-18 induced adhesion molecule expression
Hideshima et al., Oncogene 2001
(MAP Kinase Signaling System...) :
Importantly, the proteasome inhibitor PS-341 abrogated TNFalpha induced
NF-kappaB activation,
induction of ICAM-1 or
VCAM-1 , and increased adhesion of MM cells to BMSCs. Agents which act to inhibit TNFalpha may therefore abrogate the paracrine growth and survival advantage conferred by MM cell adhesion in the BM microenvironment
Park et al., Nutr Cancer 2001
:
To clarify the transcriptional regulatory pathway, we investigated the
role of
nuclear factor-kappa B (NF-kappa B) in the expression of
VCAM-1 by linoleic acid in HMEC-1 ... The
role of
NF-kappa B in linoleic acid induced
VCAM-1 expression was confirmed by functional promoter studies in HMEC-1 transfected with reporter constructs of the VCAM-1 promoter with or without mutated NF-kappa B binding site
Ochi et al., Eur J Immunol 2002
:
Transcriptional up-regulation of the
VCAM-1 gene, induced by proinflammatory cytokines such as IL-1beta and TNF-alpha,
requires activation of not only
NF-kappaB , but also involves interferon regulatory factor (IRF)-1 ... Because induction of both
VCAM-1 and E-selectin by these cytokines is
NF-kappaB dependent , we investigated whether the inhibitory effect of hyperosmotic medium might involve IRF-1
Dejardin et al., Immunity 2002
:
IKKbeta dependent activation of canonical
NF-kappaB is
required for the expression but not processing of p100 and for the expression of proinflammatory molecules including
VCAM-1 , MIP-1beta, and MIP-2 in response to LTbetaR ligation
Cui et al., Zhonghua Jie He He Hu Xi Za Zhi 2002
(Asthma...) :
NF-kappa B and AP-1 may
play important roles in the regulation of
VCAM-1 and eotaxin
Minami et al., J Biol Chem 2003
:
Taken together, these data suggest that the endothelial cell-specific effect of thrombin on
VCAM-1 expression
involves the coordinate activity of
PKC-delta-NF-kappaB and PKC-zeta-GATA signaling pathways
Li et al., Yao Xue Xue Bao 2001
:
Hydrocortisone
inhibited TNF-alpha stimulated PMN-HSC adhesion, and expression of
VCAM-1 by suppressing the activity of
NF-kappa B
Agresti et al., Biochem Biophys Res Commun 2003
:
Functionally, HMGB1 is required for the
NF-kappaB dependent expression of the adhesion molecule
VCAM-1
Neish et al., J Exp Med 1992
:
NF-kappa B-mediated activation of
VCAM1 gene expression may lead to endothelial expression of a mononuclear leukocyte adhesion molecule associated with initial events in the development of an atherosclerotic lesion
Mori et al., Life Sci 2004
:
The mechanism of suppression may involve inhibition of
NF-kappaB mediated up-regulation of
VCAM-1 expression induced by atherogenic stimuli
Wang et al., Am J Physiol Lung Cell Mol Physiol 2005
:
IL-1beta induced
VCAM-1 expression was significantly
blocked by the specific
NF-kappaB inhibitors helenalin and pyrrolidine dithiocarbamate
Manna et al., J Biol Chem 2005
:
IL-8 induces
NF-kappaB dependent reporter gene expression as well as ICAM-1,
VCAM-1 , and Cox-2 expression
Secchiero et al., Blood 2005
(Inflammation) :
Unexpectedly, the antiadhesive activity of TRAIL was not due to interference with the
nuclear factor kappaB (NF-kappaB) mediated up-regulation of surface intercellular adhesion molecule 1 ( ICAM-1 ),
vascular cell adhesion molecule 1 ( VCAM-1 ), and E-selectin adhesion molecules in response to inflammatory cytokines
Chao et al., Am J Physiol Heart Circ Physiol 2005
:
To investigate the role of FADD in CM NF-kappaB activation, we utilized adenoviral gene transfer of wild-type FADD and a truncation mutant that lacks the death-effector domain ( FADD-DED ) in rat CMs in vitro TNF-alpha activated NF-kappaB in CMs as demonstrated by phosphorylation and degradation of inhibitory-kappaB (IkappaB)-alpha enhanced nuclear p65 and NF-kappaB DNA binding activity as well as increased mRNA for the
NF-kappaB dependent adhesion molecule
VCAM-1 ( 19 +/- 4.1-fold ) as measured by quantitative RT-PCR
Kawanami et al., Atherosclerosis 2006
(Atherosclerosis) :
C-reactive protein
induces VCAM-1 gene expression through
NF-kappaB activation in vascular endothelial cells
Eto et al., Circulation 2005
:
GSK-3 regulates TNF-alpha induced IkappaB-alpha degradation and
NF-kappaB activation independent of IkappaB-kinase-beta and subsequent
induction of TF and
VCAM-1 expression in human endothelial cells
Ross et al., Blood 2006
(Inflammation) :
The alpha9beta1 signaling pathway shares significant features with the IFN-beta survival signaling pathway, requiring PI3 kinase,
NF-kappaB activation , as well as de novo protein synthesis, but the kinetics of NF-kappaB activation by
VCAM-1 were slower and more sustained compared with IFN-beta
Pae et al., Atherosclerosis 2006
(Atherosclerosis) :
Pre-treatment with HA inhibited the secretion of monocyte chemoattractant protein (MCP)-1, the expression of
vascular cell adhesion molecule (VCAM)-1 and the
activation of transcriptional
nuclear factor (NF)-kappaB in HUVECs stimulated with tumor necrosis factor-alpha, the major pro-inflammatory cytokine causing endothelial inflammation
Tsou et al., Toxicol Appl Pharmacol 2005
:
On the other hand, the TNF-alpha induced VCAM-1 expression could be completely abolished by inhibition of AP-1 or NF-kappaB activity, suggesting that activation of both AP-1 and
NF-kappaB was
necessary for
VCAM-1 expression
Lee et al., J Cell Physiol 2006
:
Here, the
roles of mitogen activated protein kinases ( MAPKs ) and
NF-kappaB in TNF-alpha induced expression of
vascular cell adhesion molecule (VCAM)-1 were investigated in human tracheal smooth muscle cells ( HTSMCs ) ... These results suggest that in HTSMCs, activation of MAPK pathways,
NF-kappaB , and p300 is
essential for TNF-alpha induced
VCAM-1 expression
Amin et al., Blood 2006
:
Antisense oligodeoxynucleotides ( ODNs ) and inhibitors of Src, PI3K, p38, and
NFkappaB significantly
reduced rhMIF induced MN
VCAM-1 and ICAM-1 expression ( P < .05 )
Mullan et al., Arthritis Rheum 2006
(Arthritis, Rheumatoid...) :
A-SAA induced expression of
VCAM-1 , ICAM-1, and MMP-1 was
down-regulated by
NF-kappaB inhibition
Reed et al., Dig Dis Sci 2005
(Colitis...) :
Colon tissue was collected for assessment of histological changes,
NF-kappa B activation , myeloperoxidase (MPO) activity, and expression of NK-1R, SP, TNFalpha, IL-1beta,
VCAM-1 , ICAM-1, E-selectin, CINC-1, MIP-1alpha, and iNOS
Chen et al., Zhonghua Shao Shang Za Zhi 2005
(Burns) :
Burn serum can enhance the expression of
VCAM-1 in HUVECs through p38 MAPK signaling pathway, and the activation of
NF-kappaB was also
involved in this process
Hosokawa et al., Clin Exp Immunol 2006
:
Both ICAM-1 and
VCAM-1 expression by HGF was
inhibited by
nuclear factor-kappaB (NF-kappaB) activation inhibitor ( MG-132 )
Ueno et al., Cardiovasc Toxicol 2006
(Atherosclerosis) :
Inhibitors of p38 MAPK, PKC, and
NF-kappaB suppressed nicotine stimulated expression of ICAM-1 and
VCAM-1
van Loo et al., Nat Immunol 2006
(Encephalomyelitis, Autoimmune, Experimental...) :
NF-kappaB inhibition
prevented the expression of proinflammatory cytokines, chemokines and the adhesion molecule
VCAM-1 from CNS-resident cells
Kawakami et al., Circulation 2006
(Atherosclerosis...) :
PKCbeta inhibition abolished apoCIII induced NF-kappaB activation, and
NF-kappaB inhibition
reduced expression of
VCAM-1 , each resulting in reduced THP-1 cell adhesion
Wong et al., Int Immunopharmacol 2006
:
However, the expression of
VCAM-1 on BEAS-2B cells was only
up-regulated by TNF-alpha induced
NF-kappaB activity
Hosokawa et al., Clin Exp Immunol 2006
(Periodontitis) :
Phosphatidylinositol 3-kinase (PI3K) and
nuclear factor-kappaB (NF-kappaB) inhibitor
inhibit both ICAM-1 and
VCAM-1 expression induced by TWEAK
Lin et al., Cell Signal 2007
:
Involvement of MAPKs and
NF-kappaB in LPS induced
VCAM-1 expression in human tracheal smooth muscle cells
Rajesh et al., Am J Physiol Heart Circ Physiol 2007
:
HG markedly increased mitochondrial superoxide generation ( measured by flow cytometry using MitoSOX ),
NF-kappaB activation , nitrotyrosine formation, upregulation of iNOS and adhesion molecules ICAM-1 and
VCAM-1 , transendothelial migration of monocytes, and monocyte-endothelial adhesion in HCAECs
Kang et al., Arthritis Rheum 2007
(Arthritis, Rheumatoid...) :
LIGHT mediated up-regulation of MMPs and intercellular adhesion molecule 1 was blocked by inhibitors of NF-kappaB and JNK, whereas up-regulation of
vascular cell adhesion molecule 1 was
blocked by inhibitors of phosphatidylinositol 3-kinase, as well as
NF-kappaB
Carluccio et al., Am J Physiol Heart Circ Physiol 2007
(Hyperhomocysteinemia) :
Homocysteine
induces VCAM-1 gene expression through
NF-kappaB and NAD ( P ) H oxidase activation : protective role of Mediterranean diet polyphenolic antioxidants ... Because VCAM-1 expression is crucial in monocyte adhesion and early atherogenesis, we evaluated the NF-kappaB related induction of VCAM-1 by homocysteine ( Hcy ) and the possible inhibitory effect of dietary polyphenolic antioxidants, such as trans-resveratrol ( RSV ) and hydroxytyrosol ( HT ), which are known inhibitors of
NF-kappaB mediated
VCAM-1 induction
Tung et al., Cell Signal 2007
:
In this study, we identified a
requirement for PDGFR, PI3-K/Akt, p38 MAPK, JNK, and
NF-kappaB in the regulation of
VCAM-1 expression by rat vascular smooth muscle cells ( VSMCs ) in response to viral infection ... Furthermore,
VCAM-1 expression induced by EV71 was significantly
attenuated by a selective
NF-kappaB inhibitor ( helenalin )
Madonna et al., Int J Immunopathol Pharmacol 2007
:
Co-treatment of HUVEC with insulin and SB202190 strongly reverted the stimulatory effect of insulin on NF-KB activation, thus establishing a link between
NF-KB activation and p38MAPkinase mediated
induction of
VCAM-1 by insulin
Lee et al., Int Immunol 2007
:
Hydrogen peroxide increases human leukocyte adhesion to porcine aortic endothelial cells via
NFkappaB dependent up-regulation of
VCAM-1 ... In summary, our results suggest that
NFkappaB dependent porcine
VCAM-1 expression by H ( 2 ) O ( 2 ) may promote interaction of human leukocyte to PAECs, and thus may play an important role on inducing xenogeneic immune responses
Zerfaoui et al., Cell Signal 2008
:
Nuclear translocation of p65
NF-kappaB is
sufficient for
VCAM-1 , but not ICAM-1, expression in TNF stimulated smooth muscle cells : Differential requirement for PARP-1 expression and interaction ... Here we show that while p65
NF-kappaB nuclear translocation in TNF treated smooth muscle cells ( SMCs ) was
sufficient for the expression of
VCAM-1 , expression of ICAM-1 showed a critical requirement for PARP-1
Lin et al., Toxicol Appl Pharmacol 2008
:
In our previous study, LPS has been shown to
induce vascular cell adhesion molecule-1 (
VCAM-1 ) expression through MAPKs and
NF-kappaB in human tracheal smooth muscle cells ( HTSMCs )
Rajan et al., J Cell Biochem 2008
:
We further demonstrated that inhibition of
NF-kappaB completely
blocked TNF-alpha induced expression of ICAM-1,
VCAM-1 and E-selectin
Wu et al., Atherosclerosis 2009
(Atherosclerosis...) :
CRH significantly up-regulated the expression of both protein and mRNA for
vascular cell adhesion molecule-1 ( VCAM-1 ), together with a markedly increased
activation of
nuclear factor kappa B (NF-kappaB) in aortas ... Meanwhile, both the enhanced expression of
VCAM-1 and increased
activation of
NF-kappaB induced by CRH in aortas of LDLr-/- mice were also largely suppressed by NBI27914, whereas these inhibitory effects were not observed in anti-Svg-30 group
El-Osta et al., J Exp Med 2008
(Diabetes Complications...) :
Both the epigenetic changes and the gene expression changes persist for at least 6 d of subsequent normal glycemia, as do
NF-kappaB induced increases in monocyte chemoattractant protein 1 and
vascular cell adhesion molecule 1 expression
Hastings et al., Arterioscler Thromb Vasc Biol 2009
(Atherosclerosis) :
Neutralization of the IL-8 receptor, CXCR2, further induced
VCAM-1 in the presence of IL-1beta, and phospho-p38 was
required for
NF-kappaB activation and VCAM-1 expression
Luo et al., Toxicol Appl Pharmacol 2009
(Second Messenger Systems) :
Activation of
ROS/NF-kappaB and Ca2+/CaM kinase II are
necessary for
VCAM-1 induction in IL-1beta treated human tracheal smooth muscle cells
Wu et al., American journal of physiology. Renal physiology 2009
(Nephritis) :
However, the broad-spectrum caspase inhibitor Boc-d-fmk reduced
NF-kB activation as assessed by gel shift assay, reduced phosphorylation of subunit IkappaBalpha, and significantly
inhibited TNF induced expression of ICAM-1 and
VCAM-1 as assessed by both real-time PCR and flow cytometry
Wang et al., Int Immunopharmacol 2009
:
Nuclear factor-kappaB (NF-kappaB) could
regulate transcription of
VCAM-1 and ICAM-1 genes
Binion et al., Am J Physiol Gastrointest Liver Physiol 2009
:
Tumor necrosis factor (TNF)-alpha/lipopolysaccharide (LPS) induced
VCAM-1 expression in HIMEC was
suppressed by Akt small interfering RNA, curcumin, and inhibitors of
NF-kappaB ( SN-50 ), p38 MAPK ( SB-203580 ) and PI 3-kinase/Akt ( LY-294002 )
Nakano et al., Hypertens Res 2009
:
Thus, telmisartan
inhibits the cytokine induced expression of the
VCAM-1 gene by blocking
NF-kappaB activation independently of PPAR gamma activation
Jiang et al., Gynecol Obstet Invest 2010
(Pre-Eclampsia) :
Protein kinase C-alpha activation induces
NF-kB dependent
VCAM-1 expression in cultured human umbilical vein endothelial cells treated with sera from preeclamptic patients
Azcutia et al., PloS one 2010
(Hyperglycemia...) :
Both ERK 1/2 and
NF-kappaB were
necessary for
VCAM-1 expression, but not for ICAM-1 expression
Zhong et al., Biochem Biophys Res Commun 2012
(MAP Kinase Signaling System) :
Omentin,
NF-kB inhibitor ( BAY11-7082 ) and ERK inhibitor ( PD98059 )
reduced the up-regulation of ICAM-1 and
VCAM-1 induced by TNF-a
Zhang et al., Biochem Biophys Res Commun 2013
(Atherosclerosis) :
Our results suggest that Ang- ( 1-7 ) mediates its affects on ECs through the Mas receptor, and negatively
regulates Ang II-induced
VCAM-1 expression by attenuating nuclear translocation of
NF-kappaB
Weber et al., Circulation 1995
:
Our data suggest that aspirin inhibits
NF-kappa B mobilization,
induction of
VCAM-1 and E-selectin, and subsequent monocyte adhesion in endothelial cells stimulated by TNF, thereby providing an additional mechanism for therapeutic effects of aspirin
Weber et al., J Immunol 1995
:
Our data suggest that specific phosphorylation following protein tyrosine kinase activation may be required for
NF-kappa B mobilization and
induction of
VCAM-1 and ELAM-1 by TNF
Cobb et al., FEBS Lett 1996
:
In this report, we investigated the effects of a 3-alkoxybenzo [ beta ] thiophene-2-carboxamide ( BZT ) on the cytokine induction of
VCAM-1 expression and
activation of the transcription factor
NF-kappa B in human endothelial cells
Shin et al., J Biol Chem 1996
:
These findings suggest that the induction of ICAM-1 and
VCAM-1 expression
requires NF-kappa B activation and that .NO attenuates IFN-gamma induced VCAM-1 expression primarily by inhibiting basal constitutive NF-kappa B activity in SMC
Udagawa et al., J Immunol 1996
:
Similar to expression of IL-2, we demonstrated that recombinant
vascular-cell adhesion molecule-1 , when co-immobilized with anti-CD3 mAb, significantly
enhanced the induction of transcription factors NF-AT, AP-1, and
NF-kappa B as determined by electromobility shift assays
Lee et al., Immunol Lett 1996
:
The
NF-kappa B inhibitor, tepoxalin,
suppresses surface expression of the cell adhesion molecules CD62E, CD11b/CD18 and
CD106
Khachigian et al., Am J Pathol 1997
:
Inducible
vascular cell adhesion molecule-1 ( VCAM-1 ) in glomerular mesangial cells ( GMC ) exposed to lipopolysaccharide (LPS) in vitro
involves the activation of
nuclear factor-kappa B (NF-kappa B) and its interaction with the proximal VCAM-1 promoter
Spiecker et al., J Biol Chem 1997
:
The induction of
vascular cell adhesion molecule-1 ( VCAM-1 ) expression by tumor necrosis factor (TNF)-alpha
requires the activation of
nuclear factor-kappaB (NF-kappaB) via a process involving the phosphorylation and degradation of its cytoplasmic inhibitor, IkappaBalpha
Hattori et al., Mol Cell Biochem 1997
:
Thus,
VCAM-1 gene expression appeared to be
mediated by
NF-kappa b in cardiac myocytes, and this cardiac myocyte VCAM-1 may be involved in cardiac inflammatory disorders
Ahmad et al., J Biol Chem 1998
:
The inflammatory response transcription factor
nuclear factor (NF)-kappaB plays an important role in the regulation of
VCAM-1 expression by various stimuli including tumor necrosis factor (TNF)-alpha
Ishizuka et al., Clin Exp Immunol 1998
:
These findings suggest that ICAM-1 or ELAM-1 expression of HUVEC stimulated via TXA2 receptors is augmented by induction of NF-kappaB and AP-1 binding activity through the PKC system, and that
VCAM-1 expression is
augmented by induction of
NF-kappaB binding activity
Oertli et al., J Immunol 1998
:
Inhibition of
NF-kappaB with the serine protease inhibitor N-tosyl-L-phenylalanine chloromethyl ketone
blocked the HA-mediated expression of ICAM-1 and
VCAM-1 in MCT cells
Lavie et al., J Biol Chem 1999
:
Since VCAM-1 expression appears developmentally regulated and cytokine-inducible in smooth muscle cells ( SMCs ), we have studied the
role of
NF-kappaB in differentiated SMC
VCAM-1 expression ... Taken together, these findings suggest that in contrast to TNF-alpha activation,
NF-kappaB is not
involved in
VCAM-1 gene expression during SMC differentiation