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SGK1 — WNK1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Xu et al., Proc Natl Acad Sci U S A 2005
(Pseudohypoaldosteronism) :
WNK1 activates
SGK1 to regulate the epithelial sodium channel ... We show that
WNK1 activates the serum- and glucocorticoid-inducible protein kinase
SGK1 , leading to activation of the epithelial sodium channel
Xu et al., J Biol Chem 2005
(Hypertension) :
WNK1 activates
SGK1 by a phosphatidylinositol 3-kinase dependent and non-catalytic mechanism ... We have been investigating actions of WNK1 and have found that
WNK1 activates the serum- and glucocorticoid induced protein kinase
SGK1 , which impacts membrane expression of the epithelial sodium channel ... Here we explore the
role of
WNK1 in
SGK1 regulation ...
Activation of
SGK1 by
WNK1 is blocked by phosphatidylinositol 3-kinase inhibitors ... Finally, we show that
WNK1 is
required for the activation of
SGK1 by insulin-like growth factor 1
Heise et al., J Biol Chem 2010
:
WNK1 activates the serum- and glucocorticoid induced protein kinase
SGK1 ; the mechanism is noncatalytic