◀ Back to CREB1
CREB1 — SP1
Pathways - manually collected, often from reviews:
-
FastForward regulation:
SP1
→
CREB1
(transcriptional regulation, unknown)
Evidence: DNABINDING, REG, PROMACTIVITY
-
FastForward regulation:
SP1
→
CREB1
(transcriptional regulation, increase)
Hong et al., Biochem J 2008*
Evidence: DNABINDING, REG, PROMACTIVITY
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
CREB1 (CREB1)
→
SP1 (SP1)
(transcription, activates)
Zhang et al., J Cell Biochem 2007
Evidence: physical interaction, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
SP1
—
CREB1
(interaction, mapped from grid)
-
STRING interaction:
CREB1
—
SP1
(interaction, mapped from grid)
Text-mined interactions from Literome
Shell et al., Biol Reprod 2002
:
Regulation of cyclic adenosine 3',5'-monophosphate response element binding protein (
CREB ) expression by
Sp1 in the mammalian testis ... Furthermore,
CREB promoter activity was
induced over 70-fold by transient overexpression of
Sp1 in SL2 cells, suggesting that Sp1 is an important regulator of CREB expression
Hilton et al., Virology 1995
:
In contrast, ICP8 mutant infected cells contained elevated amounts of NF kappa B activity equivalent to WT virus, no
induction of
Sp1 relative to WT virus, and reduced
ATF/CREB activity relative to WT virus