He et al., Zhonghua Kou Qiang Yi Xue Za Zhi 2004
:
Transient overexpression of Smad1 or Smad5 was enhanced, while overexpression of Smad6 inhibited BMP-2 induced COL1A2 promoter activity ... Smad signaling is functioning and appears to be involved in BMP-2 induced COL1A2 collagen transcription in MDPC-23
Guehring et al., Spine (Phila Pa 1976) 2005
(Intervertebral Disc Displacement) :
Gene expression analysis showed a significant up-regulation of COL1A2 , osteonectin, decorin, fibronectin, tissue inhibitor of MMP-1, BMP-2 , and MMP-13 in compressed discs