◀ Back to IL8
CXCR3 — IL8
Pathways - manually collected, often from reviews:
-
KEGG Chemokine signaling pathway:
CCL1/CCL11/CCL13/CCL14/CCL15/CCL16/CCL17/CCL18/CCL19/CCL2/CCL20/CCL21/CCL22/CCL23/CCL24/CCL25/CCL26/CCL27/CCL28/CCL3/CCL3L1/CCL3L3/CCL4/CCL4L1/CCL4L2/CCL5/CCL7/CCL8/CX3CL1/CXCL1/CXCL10/CXCL11/CXCL12/CXCL13/CXCL14/CXCL16/CXCL2/CXCL3/CXCL5/CXCL6/CXCL9/IL8/PF4/PF4V1/PPBP/XCL1/XCL2
→
CCR1/CCR10/CCR2/CCR3/CCR4/CCR5/CCR6/CCR7/CCR8/CCR9/CX3CR1/CXCR1/CXCR2/CXCR3/CXCR4/CXCR5/CXCR6/XCR1
(protein-protein, activation)
-
Reactome Reaction:
IL8
→
CXCR3
(reaction)
Lambert et al., Science signaling 2008, Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Takami et al., Brain Res Mol Brain Res 1994
Text-mined interactions from Literome
Suetomi et al., J Biol Chem 1999
:
This study demonstrates that
IL-8 recognizes and
activates CXCR1,
CXCR2 , and the Duffy antigen by distinct mechanisms
Venza et al., J Periodontol 2010
(Chronic Periodontitis...) :
These findings showed that : 1 ) in subjects without diabetes and patients with well controlled diabetes, TNF-alpha, CCR5, and
CXCR3 may constitute distinctive biomarkers of P-IM; 2 ) poor glycemic control abolished the differences between CP and P-IM regarding the expression of these mediators ; and 3 ) type 2 diabetes
affected the expression of TNF-alpha,
IL-6 and -8 , CCR5, and CXCR3
Lammers et al., Immunology 2011
(Celiac Disease) :
Identification of a novel immunomodulatory gliadin peptide that causes
interleukin-8 release in a chemokine receptor
CXCR3 dependent manner only in patients with coeliac disease
Schmitz et al., Brain Behav Immun 2013
:
Oppositely,
CXCR3-deficiency had no protective effect after traumatic nerve injury but reduced EAE evoked hyperalgesia and was associated with reduced clinical EAE scores, a reduction of the pro-inflammatory cell infiltration and
reduced upregulation of interferon gamma and
interleukin-17 in the spinal cord