◀ Back to E2F1

E2F1 — XRCC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database E2F transcription factor network: E2F1/DP complex (E2F1-TFDP2_TFDP1) → XRCC1 (XRCC1) (transcription, activates) Chen et al., J Biol Chem 2008*
  Evidence: mutant phenotype, reporter gene, physical interaction

Text-mined interactions from Literome

Chen et al., J Biol Chem 2008 (Genomic Instability) : E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair
Li et al., Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2008 : [ E2F1 upregulates endogenous XRCC1 expression ] ... [ E2F1 upregulates endogenous XRCC1 expression ] ... E2F1 could upregulate endogenous XRCC1 expression and stimulate the XRCC1 promoter
Jin et al., DNA repair 2011 : Saos2 primary osteosarcoma cells stably transfected with inducible E2F1-wt or mutant E2F1-132E were treated with hydroxurea ( HU ) for 36h and were subsequently withdrawn HU for 2-24h to test whether cell-cycle dependent DNA SSBR requires E2F1 mediated upregulation of XRCC1 ... The results indicate that E2F1 mediated regulation of XRCC1 is required for cell-cycle dependent SSBR predominantly in G ( 1 ) /S phases ... The regulation of XRCC1 by E2F1 during cell-cycle dependent SSBR might be an important aspect for practical consideration for resolving the problem of drug resistance in tumor chemotherapies