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BCL6 — STAT5A
Text-mined interactions from Literome
Dumon et al., Oncogene 1999
:
IL-3 dependent
regulation of
Bcl-xL gene expression by
STAT5 in a bone marrow derived cell line
Versteeg et al., Circ Res 2004
:
In conclusion, our results show that FVIIa induces cell survival through
STAT5 dependent
Bcl ( XL ) production and Jak2 dependent activation of PKB
Scheeren et al., Nat Immunol 2005
:
STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and
controls Bcl-6 expression
Walker et al., Oncogene 2007
(Lymphoma, B-Cell) :
STAT5 represses
BCL6 expression by binding to a regulatory region frequently mutated in lymphomas ... Therefore, we sought to determine the
effects of
STAT5 activation on
BCL6 expression and function
Qian et al., Biochim Biophys Acta 2009
(Glioma) :
To determine whether
Stat5 regulates
Bcl-xL expression in CAM induced cell death, C6-glioma was infected with an adenovirus containing a constitutively activated Stat5-GFP ( Ad-Stat5ca ) ... Overexpression of
Stat5ca increased
Bcl-xL and decreased CAM induced cell death compared to control adenovirus infected cells ; whereas Stat5 siRNA decreased DX-induced Bcl-xL and increased cell death
Tran et al., Cancer Res 2010
(Breast Neoplasms...) :
Prolactin suppression of
BCL6 was
enhanced by overexpression of
Stat5a but not Stat5b, was mimicked by constitutively active Stat5a, but did not require the transactivation domain of Stat5a
Duy et al., J Exp Med 2010
:
Although expression of BCL6 was not found in early IL-7 dependent B cell precursors, we report that
IL-7Ralpha-Stat5 signaling negatively
regulates BCL6 ... Upon productive VH-DJH gene rearrangement and expression of a mu heavy chain, however, activation of pre-B cell receptor signaling strongly
induces BCL6 expression, whereas
IL-7Ralpha-Stat5 signaling is attenuated
Walker et al., Mol Cell Biol 2013
(Breast Neoplasms) :
STAT5 , in contrast,
represses BCL6 expression below basal levels and decreases the association of RNA polymerase II at the gene