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RHOA — VAV2
Pathways - manually collected, often from reviews:
-
KEGG T cell receptor signaling pathway:
VAV1/VAV2/VAV3
→
CDC42/RHOA
(protein-protein, activation)
-
KEGG Leukocyte transendothelial migration:
VAV1/VAV2/VAV3
→
RHOA
(protein-protein, activation)
-
KEGG Chemokine signaling pathway:
VAV1/VAV2/VAV3
→
RHOA
(protein-protein, activation)
-
NCI Pathway Database Regulation of RhoA activity:
VAV2 (VAV2)
→
RHOA/GTP complex (RHOA)
(modification, activates)
Abe et al., J Biol Chem 2000, Peng et al., Cell Signal 2010*
Evidence: assay
-
NCI Pathway Database Regulation of RhoA activity:
VAV2 (VAV2)
→
RHOA/GDP complex (RHOA)
(modification, activates)
Abe et al., J Biol Chem 2000, Peng et al., Cell Signal 2010*
Evidence: assay
-
Reactome Reaction:
RHOA
→
VAV2
(reaction)
Reid et al., J Biol Chem 1999, Schmidt et al., Genes Dev 2002, Jaffe et al., Annu Rev Cell Dev Biol 2005, Chrencik et al., J Mol Biol 2008*, Ramos-Morales et al., Oncogene 1995, Pasteris et al., Cell 1994, Hart et al., J Biol Chem 1994, Hart et al., J Biol Chem 1996, Zheng et al., J Biol Chem 1996, Crespo et al., Nature 1997, Van Aelst et al., Genes Dev 1997, Ren et al., J Biol Chem 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Abe et al., J Biol Chem 2000
:
Vav2 is an
activator of Cdc42, Rac1, and
RhoA
Liu et al., Mol Cell Biol 2000
:
Vav2 activates Rac1, Cdc42, and
RhoA downstream from growth factor receptors but not beta1 integrins
Yeh et al., PloS one 2012
:
The inhibition of
Src/Vav2 attenuated the HSG mediated
RhoA activation and EC proliferation but exhibited nominal effects on ECs on LSG