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CLDN2 — EGF

Text-mined interactions from Literome

Singh et al., J Biol Chem 2004 (Neoplasms) : This study demonstrates that, in polarized Madin-Darby canine kidney II cells, EGF induced EGFR activation significantly inhibited claudin-2 expression while simultaneously inducing cellular redistribution and increased expression of claudin-1, -3, and -4 ... Accompanying these EGF induced changes in claudin expression was a 3-fold increase in transepithelial resistance, a functional measure of TJs
Chen et al., J Appl Physiol 2005 : Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells
Ikari et al., J Cell Physiol 2011 (MAP Kinase Signaling System) : Chloroquine, a lysosomal protease inhibitor, blocked the EGF induced decrease in CLDN2 protein and caused the co-localization of CLDN2 with Lamp-1, a marker of lysosome ... Monodancylcadaverine, an inhibitor of endocytosis, and clathrin siRNA blocked the EGF induced decrease in CLDN2 and the translocation of CLDN2 from the TJs to the lysosome ... EGF increased the association of CLDN2 with clathrin and adaptin a which was inhibited by U0126