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FOXO4 — SOD2

Pathways - manually collected, often from reviews:

• NCI Pathway Database FoxO family signaling: FOXO4 (FOXO4) → MNSOD (SOD2) (transcription, activates) Essers et al., EMBO J 2004
  Evidence: reporter gene

Text-mined interactions from Literome

Fallarino et al., J Exp Med 2004 : IFN-gamma-driven expression of tryptophan catabolism by CTLA-4-immunoglobulin is made possible through the concomitant activation of the Forkhead Box class O ( FOXO ) transcription factor FOXO3a, induction of the superoxide dismutase gene, and prevention of peroxynitrite formation
Araujo et al., Hum Mol Genet 2011 (Machado-Joseph Disease) : FOXO4 dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3 ... Here, we show that ATXN3 interacts with the forkhead box O ( FOXO ) transcription factor FOXO4 and activates the FOXO4 dependent transcription of the manganese superoxide dismutase ( SOD2 ) gene ... Compared with normal ATXN3, mutant ATXN3 has a reduced capability to activate the FOXO4 mediated SOD2 expression and interferes with binding of FOXO4 to the SOD2 gene promoter