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FOXP3 — HBZ
Text-mined interactions from Literome
Satou et al., PLoS Pathog 2011
(Cell Transformation, Viral...) :
As a mechanism of increased T ( reg ) cells,
HBZ expression directly
induced Foxp3 gene transcription in T cells
Zhao et al., Blood 2011
(HTLV-I Infections...) :
Finally,
HBZ expression
resulted in enhanced transcription of Pdgfb, Sox4, Ctgf,
Foxp3 , Runx1, and Tsc22d1 genes and suppression of the Id2 gene ; such effects were similar to those by TGF-ß ... In particular,
HBZ induced
Foxp3 expression in naive T cells through Smad3 dependent TGF-ß signaling