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GRB2 — PLD2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: GRB2 — PLD2 (physical association, pull down) Di Fulvio et al., Oncogene 2006*
• IRef Intact Interaction: GRB2 — PLD2 (physical association, anti tag coimmunoprecipitation) Di Fulvio et al., J Mol Biol 2007*
• IRef Intact Interaction: GRB2 — PLD2 (physical association, fluorescence microscopy) Di Fulvio et al., J Mol Biol 2007*

Text-mined interactions from Literome

Di Fulvio et al., J Mol Biol 2007 : We demonstrate that stable short hairpin RNA ( shRNA ) -based silencing of Grb2 , a critical signal transducer of the epidermal growth factor receptor (EGFR) and linker to the Ras/Erk pathway, resulted in the reduction of PLD2 activity in COS7 cells ... These results demonstrate for the first time that the presence of Grb2 and its interaction with localized intracellular structures is essential for PLD2 activity and signaling in vivo
Henkels et al., Biochem Biophys Res Commun 2009 (Cell Transformation, Neoplastic) : Affinity purified PLD2 is indeed activated by Grb2 and deactivated by CD45 in vitro