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IL13 — VEGFA

Text-mined interactions from Literome

Gloddek et al., J Endocrinol 1999 : Pituitary adenylate cyclase activating polypeptide, interleukin-6 and glucocorticoids regulate the release of vascular endothelial growth factor in pituitary folliculostellate cells
Tsuji et al., Biol Pharm Bull 2000 : Effects of sulfhydryl compounds on interleukin-1 induced vascular endothelial growth factor production in human synovial stromal cells
Corne et al., J Clin Invest 2000 (Hyperoxia) : IL-13 also stimulated VEGF accumulation in mice breathing room air, and it interacted with 100 % ( 2 ) to increase VEGF accumulation further ... They also demonstrate that IL-13 , alone and in combination with 100 % ( 2 ), stimulates pulmonary VEGF accumulation, that this stimulation is isoform-specific, and that the protective effects of IL-13 are mediated, in part, by VEGF
Elias et al., Chest 2003 (Asthma...) : The study results also demonstrated that IL-13 induces vascular endothelial growth factor , which causes bronchial circulation neovascularization in the murine airway
Inoue et al., Rheumatol Int 2005 (Osteoarthritis, Hip...) : Induction of vascular endothelial growth factor and matrix metalloproteinase-3 ( stromelysin ) by interleukin-1 in human articular chondrocytes and synoviocytes
Faffe et al., Am J Respir Cell Mol Biol 2006 : Interleukin-13 and interleukin-4 induce vascular endothelial growth factor release from airway smooth muscle cells : role of vascular endothelial growth factor genotype ... The objective of this study was to examine the mechanistic basis for IL-4- and IL-13 induced VEGF release and to determine whether genetic differences are responsible for donor-to-donor variability in VEGF release ... We measured IL-4- and IL-13 induced VEGF release in cells from 21 donors by ELISA, genotyped the cells for common single nucleotide polymorphisms in the IL-4R alpha ( Ile50Val, Ser478Pro, and Gln551Arg ) and VEGF ( -460T/C, -160C/T, -152G/A, +405C/G and +936 C/T ) genes, and stratified the data by IL-4R alpha and VEGF genotype ... IL-4 and IL-13 increased VEGF release and VEGF mRNA expression ... VEGF genotype at +405 or +936 alone had no effect on VEGF release, whereas cells bearing at least one -460C/-152A/+405G VEGF allele had lower release of VEGF in response to IL-13 or IL-4 than cells with other genotypes ... Our data suggest that IL-4 and IL-13 mediate their effects on VEGF expression post-transcriptionally and indicate that polymorphisms in the VEGF, but not the IL-4R alpha, gene affect VEGF release from smooth muscle cells
Itoh et al., Eur J Obstet Gynecol Reprod Biol 2007 : The aim of this study is to evaluate the effects of interleukin (IL)-13 , a Th2 cytokine, on the production of vascular endothelial growth factor ( VEGF ) and soluble fms-like tyrosine kinase-1 ( sFlt-1 ) in human oviductal cells in vitro ... The secretion of VEGF ( 165 ) and sFlt-1 by cultured OECs in response to IL-13 was measured using an enzyme linked immunosorbent assay
Schmeding et al., Transplantation 2010 (Fatty Liver) : Analysis of liver enzymes, histology ( hematoxylin-eosin and periodic acid Schiff stain ), immunostaining ( terminal deoxynucleotide transferase- mediated dUTP nick-end labeling, hypoxyprobe, and tumor necrosis factor-alpha ), and reverse transcriptase-polymerase chain reaction of cytokine messenger RNA ( interleukin-1 , interleukin-6, hypoxia induced factor-1 alpha, vascular endothelial growth factor , and hepatocyte growth factor ) were performed at defined time points ( 2, 4.5, 24, 48 hr, and 7 days postoperatively )
Chew et al., BMC cancer 2010 (Nasopharyngeal Neoplasms...) : The present study examined the roles of EBV latent membrane protein-1 (LMP1), interleukin-6 (IL-6), interleukin-10 (IL-10), transforming growth factor-beta 1 ( TGF-ß1 ) and laminin in the regulation of matrix-metalloproteinases ( MMPs ) and vascular endothelial growth factor ( VEGF ) in NPC
Choe et al., Joint Bone Spine 2012 (Arthritis, Rheumatoid...) : Tacrolimus ( FK506 ) inhibits interleukin-1ß induced angiopoietin-1, Tie-2 receptor, and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes
Lee et al., Proc Am Thorac Soc 2011 (Asthma...) : The former studies demonstrated that VEGF plays an important role in Th2 inflammation because, in addition to stimulating angiogenesis and edema, VEGF induced eosinophilic inflammation, mucus metaplasia, subepithelial fibrosis, myocyte hyperplasia, dendritic cell activation, and airways hyperresponsiveness via IL-13 dependent and -independent mechanisms
Ben-Av et al., FEBS Lett 1995 (Arthritis, Rheumatoid...) : Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1 : a potential mechanism for inflammatory angiogenesis
Kvanta et al., Curr Eye Res 1995 : Both interleukin-1 and transforming growth factor beta induced VEGF expression in choroidal fibroblasts although with different time courses ... By using Western blotting, it was further found that stimulation with interleukin-1 induced VEGF protein expression in choroidal fibroblasts but not in RPE cells
Matsumoto et al., Nephron 1997 (Glomerulonephritis, IGA...) : Interleukin 10 and interleukin 13 synergize to inhibit vascular permeability factor release by peripheral blood mononuclear cells from patients with lipoid nephrosis ... These results prompted us to study the effects of recombinant human IL-10 and IL-13 on VPF secretion in LN