◀ Back to PTGS2

HMOX1 — PTGS2

Text-mined interactions from Literome

Matsuoka et al., J Cereb Blood Flow Metab 1999 (Ischemic Attack, Transient) : These results suggest the following : ( 1 ) c-Jun phosphorylation was associated with ischemia/reperfusion induced neuronal apoptosis ; ( 2 ) HO-1 and COX-2 were induced in CA1 pyramidal neurons, which undergo cell death ; and ( 3 ) most CA1 pyramidal neurons expressed HO-1, COX-2 , or both, which strongly suggests that these are candidates for neuron killers
Ejima et al., Antioxid Redox Signal 2004 (Endotoxemia) : The present article reviews our recent studies involving the role of cyclooxygenase (COX)-2 in host responses to bacterial endotoxemia and its role in the regulation of nitric oxide synthase (NOS)2 and heme oxygenase (HO)-1
Krönke et al., Arterioscler Thromb Vasc Biol 2007 : Moreover, inhibition of HO-1 enzymatic activity reversed PPAR ligand mediated inhibition of cell proliferation and expression of cyclooxygenase-2 in vascular smooth muscle cells
Park et al., Neuropharmacology 2007 (Anoxia) : Taken together, we conclude that therapeutic use of NS-398 in the treatment of oxidative stress oriented neuronal disorders would be beneficial through dual actions : HO-1 induction and COX-2 inhibition
Tsoyi et al., Cell Signal 2008 : Additionally, silencing HO-1 by siRNA prevented CKD712 from inhibiting iNOS expression but not COX-2
Choi et al., Biochem Biophys Res Commun 2008 : Furthermore, SnPPIX, a HO-1 inhibitor, reversed the effects of NS-398 on PGE ( 2 ) production, suggesting that COX-2 activity can be affected by HO-1
Sue et al., Nephrol Dial Transplant 2009 (Disease Models, Animal...) : We evaluated the protective effects of HO-1 on several apoptotic parameters induced by gentamicin : cleaved caspases-3 and -9, cycloxygenase-2 (Cox-2) and subcellular localization of nuclear factor kappa B-p65 ( NF-kappaB-p65 ), Bcl-xl and HS-1 associated protein ( Hax-1 ) in NRK-52E cells
Park et al., Biochem Biophys Res Commun 2008 (Brain Infarction) : The obligatory role of COX-2 expression for induction of HO-1 in ischemic preconditioned rat brain
Saw et al., Biochem Pharmacol 2010 (Inflammation) : The combinations were also found to suppress iNOS, COX-2 , 5-lipoxygenase (5-LOX) and cPLA(2) but induce HO-1
Pi et al., J Periodontal Res 2010 : Heme oxygenase-1 mediates nicotine- and lipopolysaccharide induced expression of cyclooxygenase-2 and inducible nitric oxide synthase in human periodontal ligament cells
Park et al., Neurochem Int 2012 : We next demonstrated that ar-turmerone induced HO-1 and Nrf-2 activation suppressed the activation of neuroinflammatory molecules in LPS induced microglial cells, and that down-regulation of HO-1 signals was sufficient to induce the expression of iNOS, COX-2 and ROS production in microglial cells
Cheng et al., J Sci Food Agric 2013 (Inflammation) : A specific inhibitor of HO-1 , zinc ( II ) protoporphyrin IX, inhibited the suppression of iNOS and COX-2 expression by PV
Lee et al., Allergy, asthma & immunology research 2013 : In addition, HO-1 induction by the HO activator copper protoporphyrin suppressed LPS induced COX-2 expression, which was restored by the addition of exogenous PGE2