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MMP14 — PTGS2
Text-mined interactions from Literome
Dickens et al., J Pediatr Hematol Oncol 2003
(Bone Neoplasms...) :
Tumor development and growth were measured following treatment with a
COX-2 inhibitor ( celecoxib ), an
MMP inhibitor ( doxycycline ), or both
Okada et al., Anticancer Res 2005
:
Bis-EUG,
MMP and bis-MMP
inhibited COX-2 gene expression at concentrations of 300 microM, 500 microM and 500 microM, respectively
Spinella et al., Cancer Res 2007
(Melanoma...) :
Moreover,
COX-1/COX-2 inhibitors
block ET-induced PGE ( 2 ) and VEGF secretion,
matrix metalloproteinase ( MMP ) activation, and cell invasion, indicating that both enzymes function as downstream mediators of ET-induced invasive properties
Lee et al., Exp Mol Med 2007
(Bone Neoplasms...) :
Selective COX-2 inhibitors, NS-398 and celecoxib, inhibited cell proliferation and abrogated the enhanced mobility, invasiveness and
MMP activities
induced by
COX-2 overexpression
Hu et al., Proc Natl Acad Sci U S A 2009
(Breast Neoplasms...) :
Up-regulation of
COX-2 in DCIS xenografts
resulted in increased VEGF and
MMP14 expression, which may contribute to the larger weight and invasive histology of COX-2 expressing tumors
Annabi et al., Journal of neuroinflammation 2009
(Glioblastoma) :
MT1-MMP gene silencing antagonized COX-2 expression in neurospheres, while overexpression of recombinant
MT1-MMP directly
triggered COX-2 expression in U87 cells independent from MT1-MMP 's catalytic function ...
COX-2 induction by
MT1-MMP was also validated in wild-type and in NF-kappaB p65-/- mutant mouse embryonic fibroblasts, but was abrogated in NF-kappaB 1 ( p50-/- ) mutant cells
Khan et al., J Immunol 2012
:
In the current study, we determined whether
MMP induced
cyclooxygenase-2 expression was coupled to the expression of prostaglandin E synthase family members
Akla et al., Exp Cell Res 2012
(Inflammation) :
Concanavalin-A triggers inflammatory response through JAK/STAT3 signalling and modulates
MT1-MMP regulation of
COX-2 in mesenchymal stromal cells