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NFKBIA — PTGS2
Text-mined interactions from Literome
Díaz-Cazorla et al., J Am Soc Nephrol 1999
:
These changes in
IkappaBalpha expression could
contribute to the dual effects of NO donors on NF-kappaB activation and
COX-2 expression in HMC
Chen et al., Mol Pharmacol 2001
:
TNF-alpha- or C2-ceramide induced
COX-2 promoter activity was
inhibited by the dominant negative mutant of extracellular signal regulated kinase 2, p38, JNK,
IkappaB kinase (IKK)1 , or IKK2
Chang et al., Mol Pharmacol 2004
:
The dominant negative mutants of NIK and various
IkappaB kinase complexes, including IKKbeta ( Y188F ), IKKbeta ( Y199F ), and IKKbeta ( FF ),
inhibited the
COX-2 promoter activity
N'Guessan et al., Am J Physiol Lung Cell Mol Physiol 2006
(Pneumococcal Infections) :
A specific peptide inhibitor of the
IkappaBalpha kinase complex
blocked pneumococci induced PGE ( 2 ) release and
COX-2 expression
Zhao et al., J Cell Biochem 2007
:
In order to examine the involvement of NF-kappaB and cAMP responsive element binding protein ( CREB ) in this response, the NF-kappaB inhibitory protein IkappaBalpha or a dominant negative mutant of CREB was co-transfected into cells and the data show that transfection of either
IkappaBalpha or DN-CREB significantly
attenuated ghrelin induced
COX-2 expression
Polk et al., Am J Physiol Cell Physiol 2007
(Nephritis) :
Moreover, inhibition of
COX-2 activity
results in persistent p65-DNA binding,
IkappaBalpha phosphorylation, and IKKbeta activity, similar to that observed after prevention of RhoA/AP-1 axis signaling
Alvarez et al., Virology 2008
:
Overexpression of
IkappaBalpha completely abrogated COX-2 induction, and transfection of p65/relA NF-kappaB
induced COX-2 transcription
Shih et al., Eur J Pharmacol 2009
:
In this study, we investigated the
involvement of the extracellular signal regulated kinase ( ERK ),
IkappaB kinase alpha/beta ( IKKalpha/beta ), and nuclear factor-kappaB (NF-kappaB) signaling pathways in thrombin induced
COX-2 expression in human lung fibroblasts ( WI-38 ) ... The thrombin induced increase in
COX-2-luciferase activity was also
blocked by the dominant negative
IkappaBalpha mutant ( IkappaBalphaM )