Gene interactions and pathways from curated databases and text-mining

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NFKBIA — PTGS2

Text-mined interactions from Literome

Díaz-Cazorla et al., J Am Soc Nephrol 1999 : These changes in IkappaBalpha expression could contribute to the dual effects of NO donors on NF-kappaB activation and COX-2 expression in HMC
Chen et al., Mol Pharmacol 2001 : TNF-alpha- or C2-ceramide induced COX-2 promoter activity was inhibited by the dominant negative mutant of extracellular signal regulated kinase 2, p38, JNK, IkappaB kinase (IKK)1 , or IKK2
Chang et al., Mol Pharmacol 2004 : The dominant negative mutants of NIK and various IkappaB kinase complexes, including IKKbeta ( Y188F ), IKKbeta ( Y199F ), and IKKbeta ( FF ), inhibited the COX-2 promoter activity
N'Guessan et al., Am J Physiol Lung Cell Mol Physiol 2006 (Pneumococcal Infections) : A specific peptide inhibitor of the IkappaBalpha kinase complex blocked pneumococci induced PGE ( 2 ) release and COX-2 expression
Zhao et al., J Cell Biochem 2007 : In order to examine the involvement of NF-kappaB and cAMP responsive element binding protein ( CREB ) in this response, the NF-kappaB inhibitory protein IkappaBalpha or a dominant negative mutant of CREB was co-transfected into cells and the data show that transfection of either IkappaBalpha or DN-CREB significantly attenuated ghrelin induced COX-2 expression
Polk et al., Am J Physiol Cell Physiol 2007 (Nephritis) : Moreover, inhibition of COX-2 activity results in persistent p65-DNA binding, IkappaBalpha phosphorylation, and IKKbeta activity, similar to that observed after prevention of RhoA/AP-1 axis signaling
Alvarez et al., Virology 2008 : Overexpression of IkappaBalpha completely abrogated COX-2 induction, and transfection of p65/relA NF-kappaB induced COX-2 transcription
Shih et al., Eur J Pharmacol 2009 : In this study, we investigated the involvement of the extracellular signal regulated kinase ( ERK ), IkappaB kinase alpha/beta ( IKKalpha/beta ), and nuclear factor-kappaB (NF-kappaB) signaling pathways in thrombin induced COX-2 expression in human lung fibroblasts ( WI-38 ) ... The thrombin induced increase in COX-2-luciferase activity was also blocked by the dominant negative IkappaBalpha mutant ( IkappaBalphaM )