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ANGPT2 — CRK
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Touyz et al., Hypertension 2001
(Hypertension) :
These data demonstrate that ( 1 )
Ang II-mediated activation of
p38 and ERK1/2 is increased in SHR, ( 2 ) augmented growth responses are generated by ERK1/2 dependent, p38 MAP kinase independent pathways, and ( 3 ) p38 MAP kinase influences Ang II-induced collagen production in SHR but not in Wistar-Kyoto rats
Yoshizumi et al., Mol Pharmacol 2001
:
Our findings showed that
Ang II stimulated rapid and significant activation of extracellular signal regulated kinase ( ERK ) 1/2, c-Jun N-terminal kinase (JNK), and
p38 in RASMC
Krikun et al., Am J Pathol 2002
(Uterine Hemorrhage) :
To further examine the effects of progestin, hypoxia, and reactive oxygen species ( ROS ) on the regulation of Ang-1 and
Ang-2 as well as the
activation of MAPK, SAPK/JNK, and
p38 by the relevant cell types, we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs )
Slice et al., J Biol Chem 2005
:
Luciferase promoter assays showed that
Ang II-dependent transcriptional activation of the COX-2 promoter was
dependent on activation of small GTPases and
p38 ( MAPK ) and on Ca2+ signaling via the cAMP-responsive element/activating transcription factor cis acting element
Tabet et al., Circ Res 2008
(Hypertension) :
Ang II stimulation
increased activation of ERK1/2,
p38MAPK , and AKT, with enhanced effects in SHR. SHP-2 knockdown resulted in increased AKT phosphorylation, without effect on ERK1/2 or p38MAPK
Morales et al., Int J Biochem Cell Biol 2012
(Fibrosis) :
Furthermore, we showed that the
Ang-II dependent
p38MAPK activation, but not the ERK1/2 phosphorylation, was necessary for the NOX derived ROS
Takahashi et al., Am J Physiol 1998
:
These results indicate that
ANG II induces tyrosine phosphorylation of p130Cas and
c-Crk II and their specific association, suggesting a potential role of the p130Cas-c-Crk II complex in ANG II signal transduction in VSMC