Gene interactions and pathways from curated databases and text-mining

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APC — MMP13

Text-mined interactions from Literome

Jackson et al., Inflamm Res 2001 (Arthritis, Rheumatoid) : Recently, the serine protease, activated protein C (APC), has been shown to directly activate gelatinase A, without requiring MT-MMP Inhibition of APC represents a selective approach to prevent gelatinase A activation and may prove to be of therapeutic benefit in RA
Jackson et al., Arthritis Rheum 2009 (Disease Models, Animal...) : APC resulted in MMP-13 activation in cartilage cultures
Garvican et al., J Orthop Res 2010 : APC did not directly activate pro-MMP-13