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EDN1 — EPO
Text-mined interactions from Literome
Banerjee et al., Kidney Int 2000
:
We hypothesize that
EPO receptors (EPORs) on endothelial cells ( ECs ) in various sites of vasculature may
mediate the activities of nitric oxide synthase (NOS) and/or the release of
endothelin-1 (ET-1) , contributing to blood pressure changes
Jelkmann et al., Ann Hematol 2004
(Neoplasms) :
Epo promotes angiogenesis and
stimulates the production of
endothelin and other vasoactive mediators
Grenz et al., Naunyn Schmiedebergs Arch Pharmacol 2006
(Anoxia) :
Effect of
endothelin-1 on
erythropoietin production in a rat model under normoxia and functional carbon monoxide induced hypoxia
Shah et al., Am J Perinatol 2010
(Retinopathy of Prematurity) :
In addition to its hematopoietic effects,
erythropoietin causes an increased release of
endothelin-1 and the stimulation of angiogenesis and thereby it may have possible role in development of retinopathy of prematurity (ROP)
Simon et al., Rev Med Interne 1995
(Anemia...) :
Recently, it was demonstrated that
erythropoietin increased
endothelin-1 release by endothelial cells
Kita et al., J Immunol 1995
:
MBP ( 10 micrograms/ml ) and
EPO ( 0.1 micrograms/ml )
induced EDN release comparable with one of the strongest agonists for eosinophils, secretory IgA ... Pretreatment of cells with dibutyryl cAMP or cytochalasin B completely abolished the
EDN release
induced by MBP and
EPO , suggesting that the effects of MBP and EPO are not due to cytotoxic lysis of the cells
Hon et al., Artif Organs 1995
(Kidney Failure, Chronic) :
Lack of a fast acting
effect of
erythropoietin on arterial blood pressure and
endothelin level ... This study was designed to explore the presence, if any, of fast acting
effects of
EPO on the arterial blood pressure and
endothelin level in vivo
Katoh et al., Life Sci 1994
:
Direct evidence for
erythropoietin induced release of
endothelin from peripheral vascular tissue ... The
effect of recombinant human
erythropoietin ( r-HuEPO, 0.1 to 2.0 U/ml ) on
endothelin-1 (ET-1) release was examined in isolated hind legs perfused with Krebs-Ringer solution from normal rats
Carlini et al., Kidney Int 1993
:
Recombinant human
erythropoietin ( rHuEPO )
increases endothelin-1 release by endothelial cells
López Ongil et al., Exp Nephrol 1996
:
Recombinant human
erythropoietin does not
regulate the expression of
endothelin-1 and constitutive nitric oxide synthase in vascular endothelial cells
Haller et al., Kidney Int 1996
:
Erythropoietin (EPO) induces
endothelin expression in endothelial cells ( EC ) and has angiogenic effects
Vogel et al., Am J Hypertens 1997
(Second Messenger Systems) :
Effects of
erythropoietin on
endothelin-1 synthesis and the cellular calcium messenger system in vascular endothelial cells
Liefeldt et al., J Cardiovasc Pharmacol 1998
:
Transcriptional
regulation of
endothelin-1 by
erythropoietin in endothelial cells
Kang et al., Nephrol Dial Transplant 1998
:
Acute
effects of recombinant human
erythropoietin on plasma levels of proendothelin-1 and
endothelin-1 in haemodialysis patients