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CREBBP — ESR1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: ESR1 → Complex of CREBBP-NCOA1 (directlyIncreases, CREBBP/NCOA1 Activity)
  Evidence: The C-terminal region of the p160 proteins mediates interaction with other factors with a role in ER signaling including CBP (CREB-binding protein), p300 and arginine methyltransferase 1 (CARM-1) [32].
• OpenBEL Selventa BEL large corpus: ESR1 → Complex of CREBBP-NCOA1 (directlyIncreases, CREBBP/NCOA1 Activity)
  Evidence: ER coregulators are also targets of many of the same signaling pathways that affect ER directly. MAPK can phosphorylate p160 coactivators NCoA-1 and NCoA-3, and can enhance their transcriptional activities partly by facilitating their interaction with CBP/p300 [87,88].
• OpenBEL Selventa BEL large corpus: ESR1 → Complex of CREBBP-NCOA2 (directlyIncreases, CREBBP/NCOA2 Activity)
  Evidence: The C-terminal region of the p160 proteins mediates interaction with other factors with a role in ER signaling including CBP (CREB-binding protein), p300 and arginine methyltransferase 1 (CARM-1) [32].
• BioCarta carm1 and regulation of the estrogen receptor: Estrogen/ER alpha/Estrogen/ER alpha/GRIP1/CARM1/p300(Me)/CBP(Me) complex (CARM1-EP300-CREBBP-GRIP1-ESR1) → TF2A/TAFs/TBP/TF2F/TF2H/RNA Pol II/TF2E complex (POLR2A-GTF2F1-GTF3A-GTF2A1-GTF2E1-NR3C1) (transcription, activates)
  
• BioCarta carm1 and regulation of the estrogen receptor: Estrogen/ER alpha/Estrogen/ER alpha/GRIP1/CARM1/p300(Me)/CBP(Me) complex (CARM1-EP300-CREBBP-GRIP1-ESR1) → MEF2 polypeptide C (MEF2C) (transcription, activates)
  
• BioCarta carm1 and regulation of the estrogen receptor: Estrogen/ER alpha/Estrogen/ER alpha/GRIP1/CARM1/p300(Me)/CBP(Me) complex (CARM1-EP300-CREBBP-GRIP1-ESR1) → Estrogen/ER alpha/Estrogen/ER alpha/GRIP1/CARM1/p300(Me) complex (GRIP1-ESR1-CARM1-EP300) (modification, collaborate)
  
• BioCarta carm1 and regulation of the estrogen receptor: Estrogen/ER alpha/Estrogen/ER alpha/GRIP1/CARM1/p300(Me)/CBP(Me) complex (CARM1-EP300-CREBBP-GRIP1-ESR1) → histone transacetylase (CREBBP) (modification, collaborate)
  
• BioCarta carm1 and regulation of the estrogen receptor: Estrogen/ER alpha/Estrogen/ER alpha/GRIP1/CARM1/p300(Me) complex (GRIP1-ESR1-CARM1-EP300) → histone transacetylase (CREBBP) (modification, collaborate)
  
• BioCarta carm1 and regulation of the estrogen receptor: Estrogen/ER alpha/Estrogen/ER alpha/GRIP1/CARM1/p300(Me)/CBP(Me) complex (CARM1-EP300-CREBBP-GRIP1-ESR1) → GRIP1 (modification, collaborate)
• BioCarta carm1 and regulation of the estrogen receptor: Estrogen/ER alpha/Estrogen/ER alpha/GRIP1/CARM1/p300(Me)/CBP(Me) complex (CARM1-EP300-CREBBP-GRIP1-ESR1) → p300/CBP complex (CREBBP-EP300) (modification, collaborate)
  
• BioCarta carm1 and regulation of the estrogen receptor: Estrogen/ER alpha/Estrogen/ER alpha/GRIP1/CARM1/p300(Me)/CBP(Me) complex (CARM1-EP300-CREBBP-GRIP1-ESR1) → CARM1 (modification, collaborate)
• BioCarta carm1 and regulation of the estrogen receptor: Estrogen/ER alpha/Estrogen/ER alpha/GRIP1/CARM1/p300(Me)/CBP(Me) complex (CARM1-EP300-CREBBP-GRIP1-ESR1) → Estrogen/Estrogen/ER alpha/ER alpha complex (ESR1) (modification, collaborate)
  
• BioCarta carm1 and regulation of the estrogen receptor: p300/CBP complex (CREBBP-EP300) → Estrogen/Estrogen/ER alpha/ER alpha complex (ESR1) (modification, collaborate)
  
• NCI Pathway Database FOXA1 transcription factor network: nucleus (EP300/CREBBP) → E2/ERA complex (ESR1) (transcription, activates) Eeckhoute et al., Genes Dev 2006
  Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: ESR1 — CREBBP (physical association, affinity chromatography technology) Crowe et al., Breast Cancer Res 2006*
• IRef Biogrid Interaction: ESR1 — CREBBP (direct interaction, pull down) Sheppard et al., Mol Cell Biol 2001*
• IRef Biogrid Interaction: ESR1 — CREBBP (direct interaction, pull down) Fan et al., Cancer Res 2002*
• IRef Biogrid Interaction: ESR1 — CREBBP (physical association, affinity chromatography technology) Fan et al., Cancer Res 2002*
• IRef Biogrid Interaction: ESR1 — CREBBP (physical association, affinity chromatography technology) Jin et al., J Biol Chem 2008
• IRef Biogrid Interaction: ESR1 — CREBBP (direct interaction, two hybrid) Jaber et al., J Mol Endocrinol 2004*
• IRef Biogrid Interaction: ESR1 — CREBBP (physical association, affinity chromatography technology) Jaber et al., J Mol Endocrinol 2004*
• IRef Biogrid Interaction: ESR1 — CREBBP (direct interaction, two hybrid) Heery et al., Nature 1997*
• IRef Biogrid Interaction: ESR1 — CREBBP (physical association, affinity chromatography technology) Ku et al., J Endocrinol 2007*
• IRef Hprd Interaction: ESR1 — CREBBP (in vivo) Kamei et al., Cell 1996*
• IRef Hprd Interaction: ESR1 — CREBBP (in vitro) Kamei et al., Cell 1996*
• IRef Ophid Interaction: ESR1 — CREBBP (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Schwahn et al., Pigment Cell Res 2005 : p300/CBP was also required by ER-alpha and MITF to induce high, synergistic activation of the DCT promoter
Zheng et al., Mol Cell Biol 2005 : Together these data demonstrate that E2-induced SRC-3 phosphorylation is dependent on a direct interaction between SRC-3 and ERalpha and can occur outside of the nucleus
Hartmaier et al., Mol Endocrinol 2012 (Bone Demineralization, Pathologic...) : The coregulator steroid receptor coactivator (SRC)-1 increases transcriptional activity of the estrogen receptor ( ER ) in a number of tissues including bone
Sanchez et al., Oncogene 2013 : Coordinate regulation of estrogen receptor ß degradation by Mdm2 and CREB binding protein in response to growth signals
Suen et al., J Biol Chem 1998 : SRC-3 enhanced ERalpha and progesterone receptor stimulated gene transcription in a ligand dependent manner, but stimulation of ERbeta mediated transcription was not observed