Abdelrahim et al., Cancer Res 2006
(Breast Neoplasms) :
These results suggest that 3MC and PCB directly activate ER alpha , and this was confirmed in a competitive ER alpha binding assay and in a fluorescence resonance energy transfer experiment in which PCB and 3MC induced CFP-ER alpha/YFP-ER alpha interactions
Mortensen et al., Comparative hepatology 2007
:
This complex mode of interaction is further supported by the effect of PCB-77 on ER alpha and ER beta ( shown as increase in transcription ) with no concurrent activation of Vtg ( but Zr-protein ) response
Mortensen et al., Toxicol Appl Pharmacol 2008
:
Our data showed that PCB126 produced a time- and concentration-specific increase of ERalpha and Vtg expressions and these responses were decreased in the presence of ICI ... In general, these responses show a direct PCB126 induced transcriptional activation of ERalpha and estrogenic responses in the absence of ER agonists
Lin et al., Toxicol Lett 2009
(Breast Neoplasms) :
Protective role of estrogen receptor-alpha on lower chlorinated PCB congener induced DNA damage and repair in human tumoral breast cells