Tanaka et al., Mod Rheumatol 2012
(Arthritis, Rheumatoid...) :
STEAP4 downregulation by siRNA enhanced the expression of IL-6 mRNA, while STEAP4 overexpression suppressed IL-6 and IL-8 expression, inhibited cell proliferation, and induced apoptosis via caspase-3
Wang et al., Int J Biochem Cell Biol 2013
(Inflammation) :
In RAW264.7 macrophage cells, transient transfection of STEAP4v , to a greater extent than STEAP4, repressed the transcription of TNFa and IL-6