Gene interactions and pathways from curated databases and text-mining

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PRKCB — TNF

Text-mined interactions from Literome

Dieter et al., Cell Signal 2000 (Leukemia, Monocytic, Acute) : These results suggest that : ( 1 ) PKC-alpha but not PKC-beta is involved in the release of superoxide and PGE ( 2 ) ; ( 2 ) TNF-alpha release and the phagocytosis of latex particles are mediated by PKC-alpha, PKC-beta , and other PKC isoenzymes ; and ( 3 ) PKC-alpha and PKC-beta play antagonistic roles in the differentiation process of THP-1 cells
Radeff et al., Exp Cell Res 2001 (Bone Resorption) : PTH, tumor necrosis factor-alpha (TNF-alpha) , and interleukin-1 beta (IL-1 beta) induced translocation of PKC-alpha and -beta ( I ) to the plasma membrane in UMR-106 cells within 5 min ... The stimulation of PKC-beta ( I ) translocation by PTH, TNF-alpha or IL-1 beta was inhibited by LY379196
Aksoy et al., Eur J Immunol 2002 : Inhibition of LPS induced PKC activity using pseudosubstrate peptides specific for PKC isoforms established that PKC epsilon but not PKC alpha/beta was involved in the production of IL-12 and TNF-alpha
Ramana et al., Endocrinology 2007 : High glucose ( HG ) -induced TNF-alpha release was specifically inhibited by protein kinase C (PKC)-delta inhibitor ( Rottlerin ; EMD Biosciences, San Diego, CA ), but not PKC-beta2 inhibitor ( CGP53353 ; Tocris Cookson Inc., Ellisville, MO ), indicating the possible involvement of PKC-delta in HG signaling