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TAB1 — TNF
Pathways - manually collected, often from reviews:
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF)
(modification, collaborate)
Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TAK1/TAB family complex (MAP3K7-TAB2_TAB1)
(modification, collaborate)
Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF)
→
TAK1/TAB family complex (MAP3K7-TAB2_TAB1)
(modification, collaborate)
Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF)
(modification, collaborate)
Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF)
→
MEKK3 (MAP3K3)
(modification, collaborate)
Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF)
→
MEKK3 (MAP3K3)
(modification, collaborate)
Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF)
→
IKK complex complex (CHUK-IKBKB-IKBKG)
(modification, activates)
Devin et al., Immunity 2000, Yang et al., Nat Immunol 2001, Ducut Sigala et al., Science 2004, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Sakurai et al., J Biol Chem 1999
:
Furthermore,
tumor necrosis factor-alpha activated endogenous TAK1, and the kinase negative
TAK1 acted as a dominant negative inhibitor against tumor necrosis factor-alpha induced NF-kappaB activation
Singhirunnusorn et al., J Biol Chem 2005
:
Immunoblotting with a novel phospho-TAK1 antibody revealed that
TNF-alpha significantly
induced the phosphorylation of endogenous
TAK1 at Thr-187, and subsequently the phosphorylated forms of TAK1 rapidly disappeared ... Furthermore, SB203580 and p38alpha small interfering RNA enhanced
TNF-alpha induced Thr-187 phosphorylation as well as
TAK1 kinase activity, indicating that the phosphorylation is affected by p38alpha/TAB1/TAB2 mediated feedback control of TAK1
Bertelsen et al., Cell Signal 2007
:
In this study, a critical
role for
TAK1 in IL-1alpha or
TNFalpha stimulated MAPK and NFkappaB activation was confirmed by inhibition of the nuclear accumulation of NFkappaB p65 and phosphorylated forms of c-Jun and p38 following siRNA mediated TAK1 silencing ... Interestingly, IL-6, IL-8 and GM-CSF release from TAB1 siRNA transfected cells was significantly reduced following IL-1alpha treatment, but was unchanged after TNFalpha stimulation, suggesting differential
roles for
TAB1 in IL-1alpha and
TNFalpha signalling pathways
Sethi et al., Blood 2007
(Neoplasm Invasiveness...) :
Recent studies indicate that
TNF induced IKK activation
requires activation of
TAK1 , and we indeed found that celastrol inhibited the TAK1 induced NF-kappaB activation
Windheim et al., Biochem J 2007
:
We also show that MDP activates ERK1 ( extracellular-signal regulated kinase 1 ) /ERK2 and p38alpha MAPK in human peripheral-blood mononuclear cells and that the activity of both MAPKs and
TAK1 are
required for MDP induced signalling and production of IL-1beta and
TNFalpha in these cells
Neil et al., Cancer Res 2008
(Disease Progression) :
TAB1 ( 411 ) expression also
inhibited TGF-beta stimulated
tumor necrosis factor-alpha and cyclooxygenase-2 expression in 4T1 cells
Gardner et al., Am J Pathol 2012
(Bronchiolitis Obliterans) :
TGF-ß activated kinase 1 (TAK1) is
activated by both TGF-ß1 and
TNF-a , activating both nuclear factor kappa-light-chain-enhancer of activated B cells and mitogen activated protein kinase signaling pathways