Gene interactions and pathways from curated databases and text-mining

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TAB1 — TNF

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Sakurai et al., J Biol Chem 1999 : Furthermore, tumor necrosis factor-alpha activated endogenous TAK1, and the kinase negative TAK1 acted as a dominant negative inhibitor against tumor necrosis factor-alpha induced NF-kappaB activation
Singhirunnusorn et al., J Biol Chem 2005 : Immunoblotting with a novel phospho-TAK1 antibody revealed that TNF-alpha significantly induced the phosphorylation of endogenous TAK1 at Thr-187, and subsequently the phosphorylated forms of TAK1 rapidly disappeared ... Furthermore, SB203580 and p38alpha small interfering RNA enhanced TNF-alpha induced Thr-187 phosphorylation as well as TAK1 kinase activity, indicating that the phosphorylation is affected by p38alpha/TAB1/TAB2 mediated feedback control of TAK1
Bertelsen et al., Cell Signal 2007 : In this study, a critical role for TAK1 in IL-1alpha or TNFalpha stimulated MAPK and NFkappaB activation was confirmed by inhibition of the nuclear accumulation of NFkappaB p65 and phosphorylated forms of c-Jun and p38 following siRNA mediated TAK1 silencing ... Interestingly, IL-6, IL-8 and GM-CSF release from TAB1 siRNA transfected cells was significantly reduced following IL-1alpha treatment, but was unchanged after TNFalpha stimulation, suggesting differential roles for TAB1 in IL-1alpha and TNFalpha signalling pathways
Sethi et al., Blood 2007 (Neoplasm Invasiveness...) : Recent studies indicate that TNF induced IKK activation requires activation of TAK1 , and we indeed found that celastrol inhibited the TAK1 induced NF-kappaB activation
Windheim et al., Biochem J 2007 : We also show that MDP activates ERK1 ( extracellular-signal regulated kinase 1 ) /ERK2 and p38alpha MAPK in human peripheral-blood mononuclear cells and that the activity of both MAPKs and TAK1 are required for MDP induced signalling and production of IL-1beta and TNFalpha in these cells
Neil et al., Cancer Res 2008 (Disease Progression) : TAB1 ( 411 ) expression also inhibited TGF-beta stimulated tumor necrosis factor-alpha and cyclooxygenase-2 expression in 4T1 cells
Gardner et al., Am J Pathol 2012 (Bronchiolitis Obliterans) : TGF-ß activated kinase 1 (TAK1) is activated by both TGF-ß1 and TNF-a , activating both nuclear factor kappa-light-chain-enhancer of activated B cells and mitogen activated protein kinase signaling pathways