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ANG — SPP1
Text-mined interactions from Literome
Kupfahl et al., Cardiovasc Res 2000
:
In the human heart,
Ang II does not directly increase collagen or fibronectin mRNA, but it does
increase TGFbeta-1 and
osteopontin mRNA expression
Yu et al., Kidney Int 2000
(Disease Models, Animal...) :
The present study examined whether
OPN expression is involved in the progression of renal disease following subtotal ( 5/6 ) nephrectomy ( STNx ) in rats and whether
angiotensin II (Ang II) mediates the up-regulation of renal OPN expression and macrophage accumulation in this model by administering valsartan, an Ang II type I (AT1) receptor antagonist, or ramipril, an angiotensin converting enzyme (ACE) inhibitor
Xie et al., J Cell Physiol 2001
:
ANG II ( 1 microM, 16 h )
increased osteopontin expression ( fold increase 3.3+/-0.34, n = 12, P < 0.01 ) in CMEC as measured by northern analysis, but not in ARVM
Bruemmer et al., J Clin Invest 2003
(Aortic Aneurysm, Abdominal...) :
These data suggest an important
role for leukocyte derived
OPN in mediating
Ang II-accelerated atherosclerosis and aneurysm formation
Abe et al., Hypertens Res 2008
:
The goal of the present study was to characterize the signaling mechanisms whereby
Ang II
increases OPN expression in vascular smooth muscle cells ( VSMC )
Luther et al., Endocrinology 2009
:
Ang II did not
stimulate osteopontin or TGF-beta expression in the heart or kidney
deBlois et al., Hypertension 1996
(Hypertension) :
In vitro, smooth muscle cell expression of
osteopontin is associated with cell cycle transit or alterations in cell phenotype, and it is
increased by
angiotensin II (Ang II) stimulation