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CREB5 — TBCA
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Duric et al., Molecular pain 2007
(Inflammation...) :
Western blot analyses demonstrated that in the spinal cord,
CFA also
increased levels of phosphorylated cAMP response element binding protein (
CREB ), while in the hippocampus the activation of this transcription factor was significantly reduced, further suggesting that tissue specific transcription of either NK-1 or BDNF genes may be partially regulated by common intracellular transduction mechanisms mediated through activation of CREB
Xiao et al., Brain Res 2008
(Hyperalgesia...) :
In addition, the antisense knockdown of ERK5 reduced
CFA induced phosphorylation of cAMP response-element binding protein (
CREB ), a downstream substrate of the ERK5 pathway, and expression of Fos, a marker for neuronal activation in the central nervous system
Jang et al., Int J Mol Med 2011
(Pain) :
CFA induced phosphorylation of
CREB was inhibited by dizocilpine, but did not show marked changes