Gene interactions and pathways from curated databases and text-mining

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CDK4 — PDGFB

Text-mined interactions from Literome

Kundumani-Sridharan et al., Am J Pathol 2007 (Carotid Artery Injuries) : PDGF-BB induced cyclin D1 expression, CDK4 activity, and Rb protein phosphorylation, leading to VSMC growth and motility, and these responses were suppressed by the blockade of STAT-5B
Xu et al., Clin Exp Pharmacol Physiol 2011 : In addition, TSG significantly inhibited PDGF-BB induced phosphorylation of Rb and the expression of cyclin D1, CDK4 , cyclin E, CDK2 and PCNA
Liu et al., Mol Cell Biochem 2011 : Berberine and DHEAS decreased the expression of CDK2, CDK4 , PCNA, cyclin D1, and cyclin E, which was induced by PDGF-BB
Rao et al., Biochim Biophys Acta 1999 (Hyperplasia...) : In contrast, PDGF-BB induced depletion of p27kip1 and increased cyclins D1 and E levels and CDK2 and CDK4 activities