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IFNG — MS4A1

Text-mined interactions from Literome

Treon et al., Semin Oncol 1999 (Multiple Myeloma...) : As a potential strategy to overcome this limitation, we demonstrated that interferon-gamma at pharmacologically achievable levels induced CD20 expression on these CD20- plasma cells, consistent with our recent findings that interferon-gamma is a potent inducer of CD20 expression on MM patient plasma cells and B cells ... Our studies further suggest that interferon-gamma may enhance CD20 expression on MM plasma cells, thereby increasing their susceptibility to anti-CD20 monoclonal antibody therapies
Treon et al., Semin Oncol 2000 (Multiple Myeloma...) : The use of agents to induce MM- and WM-selective antigens for targeting in serotherapy has been proposed based on studies demonstrating the upregulation of CD20 by interferon-gamma (IFN-gamma) , and of MUC1 core protein by dexamethasone ( DEX ) on malignant plasma cells
Treon et al., J Immunother 2002 (Multiple Myeloma) : Furthermore, IFN-gamma induces CD20 expression on MM BMPCs and B cells and facilitates rituximab binding to MM BMPCs, providing the rationale for clinical trials to examine its use with CD20 directed serotherapies in MM