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ITGB2 — TNF
Text-mined interactions from Literome
Kragsbjerg et al., APMIS 2000
:
The
effects of human recombinant
tumour necrosis factor-alpha (TNF-alpha) on neutrophil ( PMNL ) oxidative burst and on
CD11b/CD18 and CD14 expression after stimulation with pathogenic or nonpathogenic Neisseria meningitidis were studied using chemiluminescence and flow cytometry ...
TNF-alpha caused a significant increase in PMNL CD
11b/CD18 expression after 30 min of incubation at 37 degrees C. TNF-alpha added simultaneously with the bacteria induced a significant increase in PMNL CD11b/CD18 in both strains
Kragsbjerg et al., Clin Microbiol Infect 2001
(Bacteremia...) :
Both S. pneumoniae and
TNF-alpha caused increases in
CD18 expression ... Live S. pneumoniae stimulates polymorphonuclear leukocytes to produce an oxidative burst and
increases expression of
CD18 , and these effects are enhanced by
TNF-alpha
Rezaie-Majd et al., Arterioscler Thromb Vasc Biol 2003
(Hypercholesterolemia) :
Moreover, simvastatin, atorvastatin, and cerivastatin were found to downregulate tumor necrosis factor
(TNF)-alpha induced expression of CD54 and
CD18/CD11a in isolated PBMCs obtained from normal donors as well as TNF-alpha dependent expression of these CAMs in cultured human umbilical vein endothelial cells ( HUVECs )
Lo et al., J Clin Invest 1992
(Pulmonary Edema) :
Tumor necrosis factor mediates experimental pulmonary edema by ICAM-1 and
CD18 dependent mechanisms
Mulligan et al., J Immunol 1992
(Inflammation) :
The current studies also demonstrated that when surface bound IgG immune complexes were treated with fresh rat serum, the increment in O2- and TNF alpha generated by alveolar macrophages was suppressed by anti-CD18, but not by anti-CD11b, suggesting a heretofore unrecognized
role for
CD18 in the O2- and
TNF-alpha responses of alveolar macrophages
Montecucco et al., Cell Signal 2008
(Inflammation) :
Tumor necrosis factor-alpha (TNF-alpha) induces integrin
CD11b/CD18 ( Mac-1 ) up-regulation and migration to the CC chemokine CCL3 ( MIP-1alpha ) on human neutrophils through defined signalling pathways ... TNF-alpha induced migration was a consequence of the
TNF-alpha induced up-regulation of integrin
CD11b/CD18 ( Mac-1 ) on neutrophil surface
Montecucco et al., J Mol Cell Cardiol 2009
(Disease Models, Animal...) :
Furthermore, JWH-133 inhibited the
TNF-alpha induced chemotaxis and integrin
CD18/CD11b ( Mac-1 ) upregulation on human neutrophils
Rea et al., Age (Dordrecht, Netherlands) 2013
(Disease Progression...) :
In 38 subjects ( mean age 85 years ), consecutively enrolled from Belfast Elderly Longitudinal Free Living Aging Study ( BELFAST ), baseline and
TNF-a stimulated
CD11b/CD18 expression on separated monocytes and neutrophils increased with systolic blood pressure > 120 mmHg ( p?=?0.05 ) and for lymphocytes, with diastolic blood pressure > 80 mmHg ( p? < ?0.05 ) .These findings show increased potential stickiness of intravascular cells with increasing blood pressure which is accentuated by TNF-a, and suggest mechanistic reasons why better hypertension control is important
Jagels et al., Blood 1995
(Leukocytosis) :
In contrast to the response to C5a,
TNF-alpha did not
cause upregulation of
CD18 or shedding of L-selectin
Windsor et al., J Clin Invest 1993
(Respiratory Distress Syndrome, Adult...) :
Tumor necrosis factor-alpha blockade
prevents neutrophil
CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation
Aramburu et al., J Immunol 1993
:
It is noteworthy that the Kp43 mediated production of
TNF-alpha was partially
inhibited by
anti-CD18 , anti-CD11a and anti-ICAM-1 mAb that blocked LFA-1 dependent cellular interactions, which impaired NK cell aggregation and, moreover, was dependent on the presence of extracellular Mg2+, thus suggesting that the leukocyte integrin is involved in the activation process triggered through Kp43
Ferrante et al., J Immunol 1993
:
TNF increased the expression of CR3 ( CD11b/CD18 ) and CR4 ( P150, 95 ; CD11c/CD18 ) adhesion receptors but not LFA-1 (
CD11a/CD18 ) ; and mAb against the alpha-chain of either CR3 or CR4 but not LFA-1 prevented the enhancing effects of TNF on the neutrophil bactericidal activity
Mukaida et al., J Leukoc Biol 1996
(Shock, Septic) :
Anti-CD18 also
prevented acute lethality induced by one of the main mediators of endotoxin shock,
TNF-alpha
Steadman et al., Int J Biochem Cell Biol 1996
:
The cell permeable diacyl glycerol, 1,2-dioctanoyl-glycerol ( DiC8 ) and
TNF alpha each
increased CD11b/CD18 expression on PMN [ maximal at 10-9 M TNF alpha or 10-8 M DiC8 ]
Kuo et al., Tuber Lung Dis 1996
(Tuberculosis, Pulmonary) :
Stimulation of AM with
TNF-alpha increased H2O2 production and
CD11b/CD18 expression
Knowles et al., Am J Physiol 1997
(Anoxia) :
During reoxygenation, both whole blood PMN phagocytosis and bactericidal activity were reduced in the
presence of IL-8,
TNF-alpha , or IL-1beta, and in subsets of PMN with reduced phagocytosis H/R reduced CD64, CD32w, CD16, CD35, and
CD11b/CD18 expression in the presence of each cytokine
Le Naour et al., AIDS Res Hum Retroviruses 1997
(HIV Infections) :
In addition, pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor, RP 55778, or with MAbs directed against IL-1beta, confirmed the
role of
TNF-alpha and IL-1beta in the regulation of
CD18 , CD44, and CD54 expression
Schmal et al., J Immunol 1998
:
As expected, cross linking of
CD18 on macrophages with Ab
resulted in generation of
TNF-alpha and MIP-2
Katano et al., Anticancer Res 1998
(Pleural Effusion, Malignant) :
Tumor necrosis factor alpha (TNF-alpha) induced
CD11b/CD18 expression on leukocytes and interferon-gamma (IFN-gamma) induced ICAM-1 expression on tumor cells may play an important role in leukocyte mediated tumor destruction