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CXCR3 — IL10
Text-mined interactions from Literome
Kremlev et al., J Neuroimmunol 2005
:
IL10 inhibited TNFalpha, MIP-1alpha, and RANTES release of LPS stimulated MG cells as well as TNFalpha, MIP-1alpha, and
CXCR3 mRNA expression by HAPI cells after exposure to LPS ( P < 0.05 )
Barbi et al., J Immunol 2008
(Genetic Predisposition to Disease...) :
Impaired induction of
CXCR3 on BALB/c T cells was not due to lack of IFN-gamma and was
mediated partially by
IL-10 but not IL-4 or IL-13
Jiang et al., Chin Med J (Engl) 2009
(Embryo Loss) :
Expression of chemokine receptors CCR3, CCR5 and
CXCR3 on CD4 ( + ) T cells in CBA/JxDBA/2 mouse model, selectively
induced by IL-4 and
IL-10 , regulates the embryo resorption rate ... This study aimed to observe whether IL-4 and
IL-10 may
regulate the expression of chemokine receptors CCR3, CCR5 and
CXCR3 on CD4 ( + ) T cells in CBA/JxDBA/2 mouse model and to explore the role of CCR3, CCR5, CXCR3 in immune tolerance in pregnancy
Schmitz et al., Brain Behav Immun 2013
:
Oppositely,
CXCR3-deficiency had no protective effect after traumatic nerve injury but reduced EAE evoked hyperalgesia and was associated with reduced clinical EAE scores, a reduction of the pro-inflammatory cell infiltration and
reduced upregulation of interferon gamma and
interleukin-17 in the spinal cord