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IFNB1 — IL10

Text-mined interactions from Literome

Lou et al., Lab Invest 1999 (Multiple Sclerosis) : Furthermore IFN-beta did not modulate the expression of adhesion molecules on either stimulated leukocytes or activated HB-MVEC, but partially reduced TNF and interleukin-1 production from stimulated leukocytes during coculture with HB-MVEC
Pacocha et al., J Interferon Cytokine Res 2000 : Finally, whereas IFN-beta inhibited antigen-driven generation of IL-5, IL-12, IL-13, and IFN-gamma, IFN-beta enhanced generation of both IL-4 and IL-10
Wang et al., J Immunol 2000 (Multiple Sclerosis) : We conclude that IFN-beta-1b has a profound inhibitory effect on PBMC IL-12 production in vitro, and that this effect is IL-10 dependent
Chabot et al., Neurology 2000 (Multiple Sclerosis) : Interferon beta-1b increases interleukin-10 in a model of T cell-microglia interaction : relevance to MS ... The enhancing effect of IFN-beta on IL-10 requires cell-cell contact, but does not seem to depend on pathways implicated in microglia-T cell interactions, involving CD40, CD23, and B7
Yao et al., J Interferon Cytokine Res 2001 : Regulation by IFN-beta of inducible nitric oxide synthase and interleukin-12/p40 in murine macrophages cultured in the presence of Chlamydia pneumoniae antigens
Hussien et al., J Neuroimmunol 2001 (Multiple Sclerosis, Chronic Progressive...) : IFN-beta also reduced IL-12, but increased IL-10 production by DCs from both MS patients and healthy controls
Dalod et al., J Exp Med 2002 : Interferon alpha/beta and interleukin 12 responses to viral infections : pathways regulating dendritic cell cytokine expression in vivo
Feng et al., J Interferon Cytokine Res 2002 : We demonstrate that IFN-alpha and IFN-beta inhibit IL-10 mRNA and protein production by activated monocytes but stimulate IL-10 production by activated T cells from the same healthy donors ... The differential IFN-beta effect on transcriptional regulation of IL-10 in monocytes and T cells was from lineage-specific modification of RNA stability ... When T cells outnumber monocytes, IFN-beta will induce IL-10 and ameliorate Th1 mediated disease
Bahner et al., Neurosci Lett 2002 (Multiple Sclerosis, Chronic Progressive) : Interferon-beta-1b increases serum interleukin-12 p40 levels in primary progressive multiple sclerosis patients
Sega et al., Clin Neurol Neurosurg 2004 (Multiple Sclerosis, Relapsing-Remitting) : These two IFN have different influences on the pattern of cytokines in MS : IFN-beta1a enhances the production of anti-inflammatory cytokines IL-4 and IL-10 and IFN-beta1b decreases the production of the proinflammatory cytokine IFN-gamma
VanDeusen et al., Eur J Immunol 2006 (Gram-Negative Bacterial Infections) : In C57BL/6 mice, early IL-10 induction occurs independently of STAT-1, while a delayed active repression of IL-10 gene expression is critically dependent on STAT-1, but only partially dependent upon IFN-alpha/beta and IFN-gamma
Fahey et al., J Leukoc Biol 2006 : IFN-beta increases the expression of the anti-inflammatory cytokine IL-10 and suppresses IL-12
Bekeredjian-Ding et al., J Immunol 2006 : Together, these results demonstrate that monocytes are licensed to synthesize IL-12p70 through type I IFN provided via the Toll/IL-1R domain containing adaptor inducing IFN-beta pathway and the inhibition of IL-10 , both provided by combined stimulation with TLR4 and TLR8 ligands, triggering a potent Th1 response before T cell help is established
Qin et al., J Immunol 2006 : IL-10 inhibits LPS induced IFN-beta gene expression and subsequent STAT-1alpha activation, but does not affect NF-kappaB activation
Fahey et al., J Leukoc Biol 2007 : Our results suggest that this may be a result of the parallel induction of IL-10 by IFN-beta
Hamamcioglu et al., Mult Scler 2007 (Disease Progression...) : In vitro, IFN-beta stimulated IL-10 production by activated T cells, but inhibited IL-10 secretion by activated monocytes, a richer source of IL-10 than T cells ... IFN-beta in vitro strongly induced IL-10 and IFN-gamma in activated T cells in RRMS, but not in progressive MS, suggesting IFN resistance
Li et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007 (Multiple Sclerosis) : IFN-beta can inhibit NK cells by inducing the inhibitory expression of CD94/NKG2A and stimulate IL-10 and TGF-beta secretion
Fahey et al., J Cell Mol Med 2007 (Multiple Sclerosis) : IFN-beta induced STAT4 phosphorylation, IL-10 production and IFN receptor ( IFNAR ) subunits 1 and 2 expression were enhanced by curcumin
Carrieri et al., Immunopharmacol Immunotoxicol 2008 (Multiple Sclerosis, Relapsing-Remitting) : We examined the effects of interferon (IFN)beta-1a on interleukin (IL)-12p70 and IL-10 secretion in 27 Relapsing Remitting Multiple Sclerosis ( RRMS ) patients, divided in responders and non-responders ... In responders, IFNbeta-1a does not change the IL-12p70 concentrations, but it leads to a remarkable increase in the IL-10 production
Marsh et al., J Neurosci 2009 (Infarction, Middle Cerebral Artery...) : TLR4 can induce both IFNbeta and interferon stimulated genes through its adapter molecule Toll/interleukin receptor domain containing adaptor inducing IFNbeta ( TRIF ) and the IRF3 transcription factor
Ramgolam et al., J Immunol 2009 (Multiple Sclerosis) : Studies of the mechanisms involved in the Th17 cell differentiation suggest that IFN-beta-1a inhibits IL-17 and induces IL-10 secretion via activated STAT1 and STAT3, respectively
Ramgolam et al., Endocr Metab Immune Disord Drug Targets 2010 (Multiple Sclerosis, Relapsing-Remitting) : The IFNbeta mediated induction of IL-10 in T-cells and B-cells represents an important additional immunoregulatory mechanism
Shirey et al., Mucosal Immunol 2010 (Lung Injury...) : TLR4 signaling is required for peroxisome proliferator activated receptor gamma expression, a DNA binding protein that induces AA-M phi genes, whereas IFN-beta regulates IL-4, IL-13, IL-4R alpha, and IL-10 expression in response to RSV
Zhang et al., Clin Neurol Neurosurg 2010 (Autoimmune Diseases...) : IFNbeta inhibited IL-1beta, IL-23 and transforming growth factor ( TGF ) -beta ( which induce Th17 cell differentiation ), and induced IL-27, IL-12p35 and IL-10 ( which suppress it ) in dendritic cells (DCs) and B-cells
Sehgal et al., Proc Natl Acad Sci U S A 1987 : The enhancement of IFN-beta 2 gene expression by diC8, interleukin 1, or tumor necrosis factor was not prevented by H8, a preferential inhibitor of cAMP- and cGMP dependent protein kinases, but was blocked by H7, an inhibitor of protein kinase C as well as of cyclic nucleotide dependent protein kinases
Kohase et al., Mol Cell Biol 1987 : Platelet derived growth factor and interleukin-1 also led to the increased expression of IFN-beta 2
Rep et al., J Neuroimmunol 1996 : Interestingly, IFN-beta enhanced secretion of IL-2 about two-fold and secretion of IL-10 nearly four-fold
Arnason et al., Clin Immunol Immunopathol 1996 (Autoimmune Diseases...) : Production of the suppressive cytokines IL-10 and transforming growth factor beta-1 is increased in vitro by IFNbeta1b
Rudick et al., Ann Neurol 1996 (Multiple Sclerosis) : Interferon beta induces interleukin-10 expression : relevance to multiple sclerosis
Cousens et al., Proc Natl Acad Sci U S A 1997 (Cytomegalovirus Infections...) : Interferon-alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection
Eloranta et al., Scand J Immunol 1997 : Priming the DC lines with tumour necrosis factor-alpha, interleukin-10 (IL-10) or IL-4 did not affect the IFN-alpha/beta response induced by HSV
McRae et al., Eur J Immunol 1997 : IFN-beta inhibited production of Th2 cytokines ( IL-5 and IL-13 ) and augmented IL-12 mediated IL-10 secretion