◀ Back to APEX1
APEX1 — PAX8
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
PAX8
→
APEX1
(increases, APEX1 Activity, PAX8 Activity)
Puppin et al., Endocrinology 2004*
Evidence: overexpression of APE/Ref-1 enhanced NIS promoter activity 2-fold. When the expression plasmid of APE/Ref-1 was transfected together with an expression plasmid for PAX8, a strong cooperative effect was detected with an increase of NIS promoter activity 9-fold over control.
Text-mined interactions from Literome
Robertson et al., Cancer Res 2001
(Carcinoma, Embryonal...) :
Moreover,
Ape1/ref-1 stimulates the DNA binding activity of transcription factors ( Fos-Jun, nuclear factor-kappaB, Myb, ATF/cyclic AMP-responsive element binding protein family, HIF-1alpha, HLF,
PAX , and p53 ) through a redox mechanism and thus represents a novel component of signal transduction processes that regulate eukaryotic gene expression
Tell et al., Horm Metab Res 2002
:
We have previously shown that
APE/Ref-1 upregulates the transcriptional activity of the thyroid-specific transcription factor
Pax8