Gorissen et al., Am J Respir Cell Mol Biol 2013
:
Wound closure in MTE cells was related to DUOX1 dependent activation of the epidermal growth factor receptor (EGFR) and the transcription factor signal transducer and activator of transcription-3 ( STAT3 ), known mediators of epithelial cell migration and wound responses
Sham et al., PloS one 2013
(Infection) :
Activation of P2Y(2)R results in recruitment of Src and DUOX1 into a signaling complex, and transient siRNA silencing or stable shRNA transfection established a critical role for DUOX1 in ATP dependent activation of Src, ADAM17, EGFR , and downstream wound responses