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CA2 — VEGFA

Text-mined interactions from Literome

Metzen et al., J Physiol 1999 (Carcinoma, Hepatocellular...) : In the presence of extracellular Ca2+ the membrane permeant calcium chelator BAPTA-AM stimulated the production of EPO ( P < 0.05 ) but not of VEGF while EGTA-AM, a closely related agent, affected neither EPO nor VEGF formation under these conditions
Tfelt-Hansen et al., Endocrinology 2003 (Leydig Cell Tumor...) : Because PTTG has been reported to induce angiogenesis, we investigated the effect of elevated Ca2+o on vascular endothelial growth factor ( VEGF ) expression
Osuka et al., Stroke 2004 (Brain Ischemia) : The vascular endothelial growth factor ( VEGF ) contributes to activation of eNOS by Ca2+/calmodulin and also stimulates the protein kinase Akt, which directly phosphorylates eNOS on Ser1177 and increases enzyme activity
Kim et al., Cell Signal 2008 (Calcium Signaling...) : The VEGF induced Ca2+ responses required Ca2+ influx, phospholipase Cgamma and Ca2+ stores ... An inhibitor of transient receptor potential canonical channels reduced the VEGF induced Ca2+ responses by 50 %, suggesting the involvement of transient receptor potential canonical channels in the VEGF mediated responses
Poteser et al., FEBS Lett 2008 : VEGF induced Ca2+ signalling was investigated in CD133+/VEGFR-2+ progenitor cells isolated from human adipose stroma
Lorenzi et al., Journal of thrombosis and haemostasis : JTH 2008 (Calcium Signaling) : Both VEGF and histamine induce a rise in cytosolic free Ca2+ ( [ Ca2+ ] c ), but the response to VEGF is weaker and even absent in a significant subset of cells
Foster et al., Am J Pathol 2008 (Calcium Signaling) : VEGF-C and VEGF-A increased [ Ca2+ ] i by 15 % and 39 %, respectively
Brock et al., Am J Pathol 1991 (Neoplasms) : Tumor secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells ... Guinea pig VPF also selectively increased [Ca2+ ] i in cultured aortic and pulmonary artery ECs, but not aortic smooth muscle cells, human fibroblasts, or neutrophils
Kim et al., Int J Cancer 2013 (Sarcoma) : In four sarcoma cell lines, HIF-1a shRNA or Dox at low concentrations blocked HIF-1a induction of VEGF-A by 84-97 % and carbonic anhydrase 9 by 83-93 %
Mukhopadhyay et al., Biochem Biophys Res Commun 1996 : Depletion of [Ca2+ ] i inhibits hypoxia induced vascular permeability factor ( vascular endothelial growth factor ) gene expression ... We have investigated the role of ion channels and intracellular Ca2+ in the regulation of hypoxia mediated VPF/VEGF activation
Höper et al., Am J Respir Cell Mol Biol 1997 : The calcium channel blocker diltiazem has no effect on the iloprost induced VEGF gene expression, and depletion of intracellular Ca2+ stores by long-term exposure ( 16 h ) of THP-1 cells to thapsigargin does not inhibit iloprost induced VEGF gene expression, suggesting that an increase in intracellular Ca2+ is not essential for VEGF gene induction by iloprost ... However, an increase of intracellular Ca2+ by a short-term ( 2 h ) exposure of THP-1 cells to thapsigargin or to the calcium-ionophore A23187 increases VEGF mRNA levels, indicating that a change in intracellular Ca2+ by itself can alter VEGF gene expression
Wellner et al., Arterioscler Thromb Vasc Biol 1999 : VEGF ( 10 ng/mL ) induced a transient increase in [Ca2+ ] i followed by a sustained elevation