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CPZ — IL10
Text-mined interactions from Literome
Tarazona et al., J Immunol 1995
(Shock, Septic) :
Whereas only low, if any, serum IL-10 levels are detectable by ELISA after injection of CPZ, bacterial LPS, or staphylococcal enterotoxin B (SEB) alone, simultaneous administration of CPZ + LPS or
CPZ + SEB
causes a significant increase in
IL-10 production in vivo ... The blockade of dopamine type 1 ( D1 ) but not type 2 ( D2 ) receptors abolishes the
CPZ effect on
IL-10 production
Mengozzi et al., Immunology 1994
:
Therefore, CPZ is a more specific inhibitor of TNF production than DEX ; in particular,
CPZ increased the induction of
IL-10 , which is a ` protective ' cytokine known to inhibit LPS toxicity and TNF production
Ikeda et al., Immunol Lett 1997
:
CPZ down-regulated tumor necrosis factor-alpha (TNF-alpha) and up-regulated
IL-10 in mice that then received ConA, whereas delayed administration of CPZ had no effect