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IFNG — PGP

Text-mined interactions from Literome

Puddu et al., Lab Invest 1999 : In this study, we investigated the effect of interferon-gamma (IFN-gamma) on the expression and activity of Pgp in human peripheral blood monocyte derived macrophages ( MDM ) ... We report that IFN-gamma up-regulated Pgp expression in a dose- and time dependent manner ... Finally, IFN-gamma stimulated the Pgp transport activity in MDM, as rhodamine 123-efflux increased in treated cells as compared with control cultures ... These results indicate that Pgp expression and activity can be up-regulated in human MDM in response to IFN-gamma
Gollapudi et al., Genes Immun 2000 : These data show that P-gp is not required for secretion of IL-2, IFN-gamma , IL-4, and IL-10 secretion in mice and IL-2 secretion in humans
Kawaguchi et al., J Pharmacol Exp Ther 2004 : Here, we investigated the effect of interferon-gamma (IFN-gamma) on the transport activity of P-gp and its expression in mice, since the cytokine is induced by various stimuli and capable of provoking a variety of cellular responses
Belliard et al., J Pharm Sci 2004 : The aim of this study was to investigate the effects of TNF alpha and IFN gamma on intestinal Pgp expression, activity, and localization in Caco-2 cells grown on filters ... By contrast, IFN gamma induced up-regulation of both mRNA MDR1 and Pgp protein expression without incidence on Pgp activity ... In conclusion, our results demonstrate an inhibitory effect of TNF alpha and no effect of IFN gamma on Pgp transport activity using rhodamine 123 as a substrate
Pawlik et al., J Pharm Pharmacol 2005 : P-gp inhibitors suppressed the release of IL-2, IL-4, IFN-gamma and TNF-alpha from PHA stimulated MNC, whereas release of IL-6 and IL-10 remained unaffected
Izawa et al., Biochem Biophys Res Commun 2010 : Moreover, P-gp blockade, compared to controls, attenuated intragraft expression of CD3 and CD80, but not CD86, and inhibited IFN-gamma and IL-4 production ( P < 0.05 ) ... In the setting of systemic CD86 inhibition, P-gp blockade suppressed IFN-gamma and IL-4 production significantly further ( to 98 % and 89 % inhibition, respectively ) compared to either P-gp or anti-CD86 blockade alone, and markedly prolonged allograft survival compared to anti-CD86 blockade alone ( 40.5+/-4.6 versus 22.5+/-2.6 days, respectively, P < 0.01 )